Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent

L. Fernández-Rhodes, E.W. Demerath, D.L. Cousminer, R. Tao, J.G. Dreyfus, T. Esko, A.V. Smith, V. Gudnason, T.B. Harris, L. Launer, P.F. McArdle, L.M. Yerges-Armstrong, C.E. Elks, D.P. Strachan, Z. Kutalik, P. Vollenweider, B. Feenstra, H.A. Boyd, A. Metspalu, E. MihailovL. Broer, M.C. Zillikens, B.A. Oostra, C.M. van Duijn, K.L. Lunetta, J.R. Perry, A. Murray, D.L. Koller, D. Lai, T. Corre, D. Toniolo, E. Albrecht, D. Stöckl, H. Grallert, C. Gieger, C. Hayward, O. Polasek, I. Rudan, J.F. Wilson, C. He, P. Kraft, F.B. Hu, D.J. Hunter, J.J. Hottenga, G. Willemsen, D.I. Boomsma, E.M. Byrne, N.G. Martin, G.W. Montgomery, N.M. Warrington, C.E. Pennell, L. Stolk, J.A. Visser, A. Hofman, A.G. Uitterlinden, F. Rivadeneira, P. Lin, S.L. Fisher, L.J. Bierut, L. Crisponi, E. Porcu, M. Mangino, G. Zhai, T.D. Spector, J.E. Buring, L.M. Rose, P.M. Ridker, C. Poole, J.N. Hirschhorn, J.M. Murabito, D.I. Chasman, E. Widén, K.E. North, K.K. Ong, N. Franceschini

Research output: Contribution to JournalArticleAcademicpeer-review


Obesity is of global health concern. There are well-described inverse relationships between female pubertal timing and obesity. Recent genome-wide association studies of age at menarche identified several obesity-related variants. Using data from the ReproGen Consortium, we employed meta-analytical techniques to estimate the associations of 95 a priori and recently identified obesity-related (body mass index (weight (kg)/height (m)
Original languageEnglish
Pages (from-to)451-460
JournalAmerican Journal of Epidemiology
Issue number3
Publication statusPublished - 2013

Cohort Studies

  • Netherlands Twin Register (NTR)


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