Abstract
Several lines of evidence have indicated that depression might be a prodromal symptom of Alzheimer's disease (AD). This systematic review and meta-analysis investigated the cross-sectional association between amyloid-beta, one of the key pathologies defining AD, and depression or depressive symptoms in older adults without dementia. A systematic search in PubMed yielded 689 peer-reviewed articles. After full-text screening, nine CSF studies, 11 PET studies, and five plasma studies were included. No association between amyloid-beta and depression or depressive symptoms were found using cerebrospinal fluid (CSF) (0.15; 95% CI: -0.08; 0.37), positron emission topography (PET) (Cohen's d: 0.09; 95% CI: -0.05; 0.24), or plasma (-0.01; 95% CI: -0.23; 0.22). However, subgroup analyses revealed an association in plasma studies of individuals with cognitive impairment. A trend of an association was found in the studies using CSF and PET. This systematic review and meta-analysis suggested that depressive symptoms may be part of the prodromal stage of dementia.
| Original language | English |
|---|---|
| Article number | 25 |
| Pages (from-to) | 1-12 |
| Number of pages | 12 |
| Journal | Translational Psychiatry |
| Volume | 14 |
| Early online date | 15 Jan 2024 |
| DOIs | |
| Publication status | Published - 2024 |
Bibliographical note
© 2024. The Author(s).Funding
This study was conducted as part of the Netherlands Consortium of Dementia Cohorts (NCDC). NCDC receives funding in the Deltaplan Dementie from ZonMw (Project number 73305095005) and Alzheimer Nederland. This study was also supported by Alzheimer Nederland grant WE.03.2021-09. The chair of W.M. van der Flier is supported by the Pasman stichting. WF is recipient of HBC-X, which has received funding from the Dutch Heart Foundation under grant agreement 2018-28. This study was conducted as part of the Netherlands Consortium of Dementia Cohorts (NCDC). NCDC receives funding in the Deltaplan Dementie from ZonMw (Project number 73305095005) and Alzheimer Nederland. This study was also supported by Alzheimer Nederland grant WE.03.2021-09. The chair of W.M. van der Flier is supported by the Pasman stichting. WF is recipient of HBC-X, which has received funding from the Dutch Heart Foundation under grant agreement 2018-28.
| Funders | Funder number |
|---|---|
| Netherlands Consortium of Dementia Cohorts | |
| ZonMw | 73305095005 |
| Hartstichting | 2018-28 |
| Alzheimer Nederland | WE.03.2021-09 |
Keywords
- Aged
- Humans
- Amyloid beta-Peptides/cerebrospinal fluid
- Biomarkers
- Cognitive Dysfunction/diagnosis
- Cross-Sectional Studies
- Depression
- Positron-Emission Tomography
- tau Proteins/cerebrospinal fluid