Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults: a monozygotic twin study

Elles Konijnenberg, Anouk den Braber, Mara ten Kate, Jori Tomassen, Sandra D. Mulder, Maqsood Yaqub, Charlotte E. Teunissen, Adriaan A. Lammertsma, Bart N.M. van Berckel, Philip Scheltens, Dorret I. Boomsma, Pieter Jelle Visser

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Amyloid pathology in cognitively normal older adults has been associated with low memory performance and cognitive complaints, but findings are conflicting. Using a monozygotic twin design, we further explored this relation. We investigated 199 cognitively normal older adults (96 twin pairs) and assessed cognitive performance, cognitive complaints, and amyloid pathology on positron emission tomography and in the cerebrospinal fluid (CSF). Participants were on average 70.5 (SD = 7.6) years and 114 (57%) were female. Amyloid–positron emission tomography abnormality on visual read and lower CSF amyloid-β 1-42/1-40 ratio were associated with lower Rey visuospatial memory performance (respectively, β = −0.39 [SE = 0.17], p = 0.02 and β = 0.15 [SE = 0.07], p = 0.04). Twin analyses showed that CSF amyloid-β 1-42/1-40 ratio in one twin of a pair could predict visuospatial memory performance in the cotwin (r = 0.20 [SE = 0.10], p = 0.04). Monozygotic twin discordance analyses further showed a probable effect of disease staging on face-name associative memory performance. Our results suggest amyloid aggregation to be associated with lower visuospatial and face-name–associated memory performance in cognitively normal older adults, supporting the view that amyloid pathology leads to memory dysfunction in very early stages of the disease.

Original languageEnglish
Pages (from-to)58-65
Number of pages8
JournalNeurobiology of Aging
Volume77
Early online date21 Jan 2019
DOIs
Publication statusPublished - May 2019

Fingerprint

Twin Studies
Monozygotic Twins
Amyloid
Pathology
Cerebrospinal Fluid
Positron-Emission Tomography
Names
Tomography

Keywords

  • Amyloid aggregation
  • Cognitive complaints
  • Memory performance
  • Monozygotic twins

Cite this

Konijnenberg, Elles ; den Braber, Anouk ; ten Kate, Mara ; Tomassen, Jori ; Mulder, Sandra D. ; Yaqub, Maqsood ; Teunissen, Charlotte E. ; Lammertsma, Adriaan A. ; van Berckel, Bart N.M. ; Scheltens, Philip ; Boomsma, Dorret I. ; Visser, Pieter Jelle. / Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults : a monozygotic twin study. In: Neurobiology of Aging. 2019 ; Vol. 77. pp. 58-65.
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abstract = "Amyloid pathology in cognitively normal older adults has been associated with low memory performance and cognitive complaints, but findings are conflicting. Using a monozygotic twin design, we further explored this relation. We investigated 199 cognitively normal older adults (96 twin pairs) and assessed cognitive performance, cognitive complaints, and amyloid pathology on positron emission tomography and in the cerebrospinal fluid (CSF). Participants were on average 70.5 (SD = 7.6) years and 114 (57{\%}) were female. Amyloid–positron emission tomography abnormality on visual read and lower CSF amyloid-β 1-42/1-40 ratio were associated with lower Rey visuospatial memory performance (respectively, β = −0.39 [SE = 0.17], p = 0.02 and β = 0.15 [SE = 0.07], p = 0.04). Twin analyses showed that CSF amyloid-β 1-42/1-40 ratio in one twin of a pair could predict visuospatial memory performance in the cotwin (r = 0.20 [SE = 0.10], p = 0.04). Monozygotic twin discordance analyses further showed a probable effect of disease staging on face-name associative memory performance. Our results suggest amyloid aggregation to be associated with lower visuospatial and face-name–associated memory performance in cognitively normal older adults, supporting the view that amyloid pathology leads to memory dysfunction in very early stages of the disease.",
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author = "Elles Konijnenberg and {den Braber}, Anouk and {ten Kate}, Mara and Jori Tomassen and Mulder, {Sandra D.} and Maqsood Yaqub and Teunissen, {Charlotte E.} and Lammertsma, {Adriaan A.} and {van Berckel}, {Bart N.M.} and Philip Scheltens and Boomsma, {Dorret I.} and Visser, {Pieter Jelle}",
note = "Copyright {\circledC} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
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Konijnenberg, E, den Braber, A, ten Kate, M, Tomassen, J, Mulder, SD, Yaqub, M, Teunissen, CE, Lammertsma, AA, van Berckel, BNM, Scheltens, P, Boomsma, DI & Visser, PJ 2019, 'Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults: a monozygotic twin study' Neurobiology of Aging, vol. 77, pp. 58-65. https://doi.org/10.1016/j.neurobiolaging.2019.01.006

Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults : a monozygotic twin study. / Konijnenberg, Elles; den Braber, Anouk; ten Kate, Mara; Tomassen, Jori; Mulder, Sandra D.; Yaqub, Maqsood; Teunissen, Charlotte E.; Lammertsma, Adriaan A.; van Berckel, Bart N.M.; Scheltens, Philip; Boomsma, Dorret I.; Visser, Pieter Jelle.

In: Neurobiology of Aging, Vol. 77, 05.2019, p. 58-65.

Research output: Contribution to JournalArticleAcademicpeer-review

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T1 - Association of amyloid pathology with memory performance and cognitive complaints in cognitively normal older adults

T2 - a monozygotic twin study

AU - Konijnenberg, Elles

AU - den Braber, Anouk

AU - ten Kate, Mara

AU - Tomassen, Jori

AU - Mulder, Sandra D.

AU - Yaqub, Maqsood

AU - Teunissen, Charlotte E.

AU - Lammertsma, Adriaan A.

AU - van Berckel, Bart N.M.

AU - Scheltens, Philip

AU - Boomsma, Dorret I.

AU - Visser, Pieter Jelle

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/5

Y1 - 2019/5

N2 - Amyloid pathology in cognitively normal older adults has been associated with low memory performance and cognitive complaints, but findings are conflicting. Using a monozygotic twin design, we further explored this relation. We investigated 199 cognitively normal older adults (96 twin pairs) and assessed cognitive performance, cognitive complaints, and amyloid pathology on positron emission tomography and in the cerebrospinal fluid (CSF). Participants were on average 70.5 (SD = 7.6) years and 114 (57%) were female. Amyloid–positron emission tomography abnormality on visual read and lower CSF amyloid-β 1-42/1-40 ratio were associated with lower Rey visuospatial memory performance (respectively, β = −0.39 [SE = 0.17], p = 0.02 and β = 0.15 [SE = 0.07], p = 0.04). Twin analyses showed that CSF amyloid-β 1-42/1-40 ratio in one twin of a pair could predict visuospatial memory performance in the cotwin (r = 0.20 [SE = 0.10], p = 0.04). Monozygotic twin discordance analyses further showed a probable effect of disease staging on face-name associative memory performance. Our results suggest amyloid aggregation to be associated with lower visuospatial and face-name–associated memory performance in cognitively normal older adults, supporting the view that amyloid pathology leads to memory dysfunction in very early stages of the disease.

AB - Amyloid pathology in cognitively normal older adults has been associated with low memory performance and cognitive complaints, but findings are conflicting. Using a monozygotic twin design, we further explored this relation. We investigated 199 cognitively normal older adults (96 twin pairs) and assessed cognitive performance, cognitive complaints, and amyloid pathology on positron emission tomography and in the cerebrospinal fluid (CSF). Participants were on average 70.5 (SD = 7.6) years and 114 (57%) were female. Amyloid–positron emission tomography abnormality on visual read and lower CSF amyloid-β 1-42/1-40 ratio were associated with lower Rey visuospatial memory performance (respectively, β = −0.39 [SE = 0.17], p = 0.02 and β = 0.15 [SE = 0.07], p = 0.04). Twin analyses showed that CSF amyloid-β 1-42/1-40 ratio in one twin of a pair could predict visuospatial memory performance in the cotwin (r = 0.20 [SE = 0.10], p = 0.04). Monozygotic twin discordance analyses further showed a probable effect of disease staging on face-name associative memory performance. Our results suggest amyloid aggregation to be associated with lower visuospatial and face-name–associated memory performance in cognitively normal older adults, supporting the view that amyloid pathology leads to memory dysfunction in very early stages of the disease.

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