Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration: Evidence from the Canadian Longitudinal Study on Aging

Divya Joshi; Frank J van Lenthe; Martijn Huisman; Erik R Sund; Steinar Krokstad; Mauricio Avendano; Parminder Raina

doi:10.1093/gerona/glad118

Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration: Evidence from the Canadian Longitudinal Study on Aging

Divya Joshi, Frank J van Lenthe, Martijn Huisman, Erik R Sund, Steinar Krokstad, Mauricio Avendano, Parminder Raina

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Neighborhood deprivation and depression have been linked to epigenetic age acceleration. The next-generation epigenetic clocks including the DNA methylation (DNAm) GrimAge, and PhenoAge have incorporated clinical biomarkers of physiological dysregulation by selecting cytosine-phosphate-guanine sites that are associated with risk factors for disease, and have shown improved accuracy in predicting morbidity and time-to-mortality compared to the first-generation clocks. The aim of this study is to examine the association between neighborhood deprivation and DNAm GrimAge and PhenoAge acceleration in adults, and assess interaction with depressive symptoms.

METHODS: The Canadian Longitudinal Study on Aging recruited 51 338 participants aged 45-85 years across provinces in Canada. This cross-sectional analysis is based on a subsample of 1 445 participants at baseline (2011-2015) for whom epigenetic data were available. Epigenetic age acceleration (years) was assessed using the DNAm GrimAge and PhenoAge, and measured as residuals from regression of the biological age on chronological age.

RESULTS: A greater neighborhood material and/or social deprivation compared to lower deprivation (b = 0.66; 95% confidence interval [CI] = 0.21, 1.12) and depressive symptoms scores (b = 0.07; 95% CI = 0.01, 0.13) were associated with higher DNAm GrimAge acceleration. The regression estimates for these associations were higher but not statistically significant when epigenetic age acceleration was estimated using DNAm PhenoAge. There was no evidence of a statistical interaction between neighborhood deprivation and depressive symptoms.

CONCLUSIONS: Depressive symptoms and neighborhood deprivation are independently associated with premature biological aging. Policies that improve neighborhood environments and address depression in older age may contribute to healthy aging among older adults living in predominantly urban areas.

Original language	English
Article number	glad118
Pages (from-to)	1-8
Number of pages	8
Journal	The journals of gerontology. Series A, Biological sciences and medical sciences
Volume	79
Issue number	2
Early online date	5 Jun 2023
DOIs	https://doi.org/10.1093/gerona/glad118
Publication status	Published - Feb 2024

Bibliographical note

Funding

This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation, as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. This research has been conducted using the CLSA dataset Baseline Comprehensive Dataset version 4.0, Tracking Baseline version 3.4, CLSA Sample Weights version 1.2, and CANUE, under Application Number 171013. The CLSA is led by Drs. Parminder Raina, Christina Wolfson and Susan Kirkland. Parminder Raina holds the Raymond and Margaret Labarge Chair in Optimal Aging and Knowledge Application for Optimal Aging, is the Director of the McMaster Institute for Research on Aging and the Labarge Centre for Mobility in Aging and holds a Tier 1 Canada Research Chair in Geroscience. This study was partly supported by the European Union Horizon2020 Programme (667661; Promoting depressed affect in the aging populationMINDMAP).

Funders	Funder number
McMaster Institute for Research on Aging, McMaster University
Government of Canada
Canada Foundation for Innovation
British Columbia
Labarge Centre for Mobility in Aging
Canadian Institutes of Health Research	LSA 94473
Canadian Institutes of Health Research
CANUE	171013
European Union Horizon2020 Programme	667661

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glad118_Association of neighborhood deprivation and depressive symptoms with epigenetic age accelerationFinal published version, 335 KBLicence: Article 25fa Dutch Copyright Act

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Joshi, D., van Lenthe, F. J., Huisman, M., Sund, E. R., Krokstad, S., Avendano, M., & Raina, P. (2024). Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration: Evidence from the Canadian Longitudinal Study on Aging. The journals of gerontology. Series A, Biological sciences and medical sciences, 79(2), 1-8. Article glad118. https://doi.org/10.1093/gerona/glad118

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title = "Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration: Evidence from the Canadian Longitudinal Study on Aging",

abstract = "BACKGROUND: Neighborhood deprivation and depression have been linked to epigenetic age acceleration. The next-generation epigenetic clocks including the DNA methylation (DNAm) GrimAge, and PhenoAge have incorporated clinical biomarkers of physiological dysregulation by selecting cytosine-phosphate-guanine sites that are associated with risk factors for disease, and have shown improved accuracy in predicting morbidity and time-to-mortality compared to the first-generation clocks. The aim of this study is to examine the association between neighborhood deprivation and DNAm GrimAge and PhenoAge acceleration in adults, and assess interaction with depressive symptoms.METHODS: The Canadian Longitudinal Study on Aging recruited 51 338 participants aged 45-85 years across provinces in Canada. This cross-sectional analysis is based on a subsample of 1 445 participants at baseline (2011-2015) for whom epigenetic data were available. Epigenetic age acceleration (years) was assessed using the DNAm GrimAge and PhenoAge, and measured as residuals from regression of the biological age on chronological age.RESULTS: A greater neighborhood material and/or social deprivation compared to lower deprivation (b = 0.66; 95% confidence interval [CI] = 0.21, 1.12) and depressive symptoms scores (b = 0.07; 95% CI = 0.01, 0.13) were associated with higher DNAm GrimAge acceleration. The regression estimates for these associations were higher but not statistically significant when epigenetic age acceleration was estimated using DNAm PhenoAge. There was no evidence of a statistical interaction between neighborhood deprivation and depressive symptoms.CONCLUSIONS: Depressive symptoms and neighborhood deprivation are independently associated with premature biological aging. Policies that improve neighborhood environments and address depression in older age may contribute to healthy aging among older adults living in predominantly urban areas.",

author = "Divya Joshi and {van Lenthe}, {Frank J} and Martijn Huisman and Sund, {Erik R} and Steinar Krokstad and Mauricio Avendano and Parminder Raina",

note = "{\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected].",

year = "2024",

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Joshi, D, van Lenthe, FJ, Huisman, M, Sund, ER, Krokstad, S, Avendano, M & Raina, P 2024, 'Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration: Evidence from the Canadian Longitudinal Study on Aging', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 79, no. 2, glad118, pp. 1-8. https://doi.org/10.1093/gerona/glad118

Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration: Evidence from the Canadian Longitudinal Study on Aging. / Joshi, Divya; van Lenthe, Frank J; Huisman, Martijn et al.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 79, No. 2, glad118, 02.2024, p. 1-8.

Research output: Contribution to Journal › Article › Academic › peer-review

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T1 - Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration

T2 - Evidence from the Canadian Longitudinal Study on Aging

AU - Joshi, Divya

AU - van Lenthe, Frank J

AU - Huisman, Martijn

AU - Sund, Erik R

AU - Krokstad, Steinar

AU - Avendano, Mauricio

AU - Raina, Parminder

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N2 - BACKGROUND: Neighborhood deprivation and depression have been linked to epigenetic age acceleration. The next-generation epigenetic clocks including the DNA methylation (DNAm) GrimAge, and PhenoAge have incorporated clinical biomarkers of physiological dysregulation by selecting cytosine-phosphate-guanine sites that are associated with risk factors for disease, and have shown improved accuracy in predicting morbidity and time-to-mortality compared to the first-generation clocks. The aim of this study is to examine the association between neighborhood deprivation and DNAm GrimAge and PhenoAge acceleration in adults, and assess interaction with depressive symptoms.METHODS: The Canadian Longitudinal Study on Aging recruited 51 338 participants aged 45-85 years across provinces in Canada. This cross-sectional analysis is based on a subsample of 1 445 participants at baseline (2011-2015) for whom epigenetic data were available. Epigenetic age acceleration (years) was assessed using the DNAm GrimAge and PhenoAge, and measured as residuals from regression of the biological age on chronological age.RESULTS: A greater neighborhood material and/or social deprivation compared to lower deprivation (b = 0.66; 95% confidence interval [CI] = 0.21, 1.12) and depressive symptoms scores (b = 0.07; 95% CI = 0.01, 0.13) were associated with higher DNAm GrimAge acceleration. The regression estimates for these associations were higher but not statistically significant when epigenetic age acceleration was estimated using DNAm PhenoAge. There was no evidence of a statistical interaction between neighborhood deprivation and depressive symptoms.CONCLUSIONS: Depressive symptoms and neighborhood deprivation are independently associated with premature biological aging. Policies that improve neighborhood environments and address depression in older age may contribute to healthy aging among older adults living in predominantly urban areas.

AB - BACKGROUND: Neighborhood deprivation and depression have been linked to epigenetic age acceleration. The next-generation epigenetic clocks including the DNA methylation (DNAm) GrimAge, and PhenoAge have incorporated clinical biomarkers of physiological dysregulation by selecting cytosine-phosphate-guanine sites that are associated with risk factors for disease, and have shown improved accuracy in predicting morbidity and time-to-mortality compared to the first-generation clocks. The aim of this study is to examine the association between neighborhood deprivation and DNAm GrimAge and PhenoAge acceleration in adults, and assess interaction with depressive symptoms.METHODS: The Canadian Longitudinal Study on Aging recruited 51 338 participants aged 45-85 years across provinces in Canada. This cross-sectional analysis is based on a subsample of 1 445 participants at baseline (2011-2015) for whom epigenetic data were available. Epigenetic age acceleration (years) was assessed using the DNAm GrimAge and PhenoAge, and measured as residuals from regression of the biological age on chronological age.RESULTS: A greater neighborhood material and/or social deprivation compared to lower deprivation (b = 0.66; 95% confidence interval [CI] = 0.21, 1.12) and depressive symptoms scores (b = 0.07; 95% CI = 0.01, 0.13) were associated with higher DNAm GrimAge acceleration. The regression estimates for these associations were higher but not statistically significant when epigenetic age acceleration was estimated using DNAm PhenoAge. There was no evidence of a statistical interaction between neighborhood deprivation and depressive symptoms.CONCLUSIONS: Depressive symptoms and neighborhood deprivation are independently associated with premature biological aging. Policies that improve neighborhood environments and address depression in older age may contribute to healthy aging among older adults living in predominantly urban areas.

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DO - 10.1093/gerona/glad118

M3 - Article

C2 - 37279588

SN - 1079-5006

VL - 79

SP - 1

EP - 8

JO - The journals of gerontology. Series A, Biological sciences and medical sciences

JF - The journals of gerontology. Series A, Biological sciences and medical sciences

IS - 2

M1 - glad118

ER -

Joshi D, van Lenthe FJ, Huisman M, Sund ER, Krokstad S, Avendano M et al. Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration: Evidence from the Canadian Longitudinal Study on Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024 Feb;79(2):1-8. glad118. Epub 2023 Jun 5. doi: 10.1093/gerona/glad118

Association of neighborhood deprivation and depressive symptoms with epigenetic age acceleration: Evidence from the Canadian Longitudinal Study on Aging

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