Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study

Adriana J. van Ballegooijen; Leila Zelnick; Andrew N. Hoofnagle; Naomi M. Hamburg; Cassiane Robinson-Cohen; Prabir Roy-Chaudhury; Alfred K. Cheung; Yan Ting Shiu; Ian H. de Boer; Jonathan Himmelfarb; Gerald Beck; Peter B. Imrey; John W. Kusek; Bryan Kestenbaum; on behalf of the; Hemodialysis Fistula Maturation (HFM) Study Group

doi:10.1053/j.ajkd.2017.01.049

Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study

Adriana J. van Ballegooijen^*, Leila Zelnick, Andrew N. Hoofnagle, Naomi M. Hamburg, Cassiane Robinson-Cohen, Prabir Roy-Chaudhury, Alfred K. Cheung, Yan Ting Shiu, Ian H. de Boer, Jonathan Himmelfarb, Gerald Beck, Peter B. Imrey, John W. Kusek, Bryan Kestenbaum, on behalf of the, Hemodialysis Fistula Maturation (HFM) Study Group

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background Disturbances in vitamin D metabolism are common in patients with end-stage renal disease and may contribute to vascular dysfunction. Study Design Cross-sectional. Setting & Participants We evaluated 558 of 602 participants at baseline of the Hemodialysis Fistula Maturation (HFM) Study, a 7-center prospective cohort study of a cohort of patients with chronic kidney disease awaiting arteriovenous fistula (AVF) creation surgery. Factor 4 vitamin D metabolites measured with liquid chromatography–tandem mass spectroscopy from samples obtained within 4 weeks prior to AVF surgery. Outcomes Vasodilator functions and measurements of arterial stiffness. Measurements Trained HFM Study personnel measured brachial artery flow-mediated dilation, nitroglycerin-mediated dilation, and carotid-femoral and carotid-radial pulse wave velocities (PWVs) prior to AVF creation. We evaluated associations after basic adjustment for sex, age, and clinical site and more fully adjusted additionally for baseline education, smoking, body mass index, diabetes, dialysis status, and medication use. Results Mean participant age was 55 ± 13 (SD) years and 65% were receiving maintenance dialysis. None of the vitamin D metabolites were significantly associated with flow-mediated dilation, carotid-femoral PWV, or carotid-radial PWV in basic or fully adjusted analyses. Higher serum concentrations of bioavailable vitamin D and 1,25-dihydroxyvitamin D were associated with 0.62% and 0.58% greater nitroglycerin-mediated dilation values, respectively, in basic models; however, these associations were no longer statistically significant with full adjustment. There were no significant associations of vitamin D metabolites with carotid-femoral or carotid-radial PWV in fully adjusted analyses. Limitations Cross-sectional ascertainment of vitamin D metabolites and vascular functions late during the course of kidney disease. Conclusions Serum concentrations of vitamin D metabolites are not associated with vasodilator functions or vascular stiffness at baseline in a cohort study of patients with chronic kidney disease awaiting AVF creation surgery. Laboratory measurements of vitamin D metabolites are unlikely to provide useful information regarding vascular functions in this setting.

Original language	English
Pages (from-to)	805-814
Number of pages	10
Journal	American Journal of Kidney Diseases
Volume	69
Issue number	6
DOIs	https://doi.org/10.1053/j.ajkd.2017.01.049
Publication status	Published - 1 Jun 2017

Funding

Support: The HFM Study is funded by the following grants from the National Institute of Diabetes and Digestive and Kidney Diseases: U01DK066597, U01DK082179, U01DK082189, U01DK082218, U01DK082222, U01DK082236, and U01DK082240. This ancillary study was funded by grant R01 DK094891 and by an unrestricted fund from the Northwest Kidney Centers and by the Niels Stensen Fellowship 2014. None of the funders of this study had any role in the collection, analysis, and interpretation of data for this study.

Funders	Funder number
National Institute of Diabetes and Digestive and Kidney Diseases	U01DK082179, U01DK082189, U01DK082222, R01 DK094891, U01DK082240, U01DK082218, U01DK066597, U01DK082236
Northwest Kidney Centers

Keywords

arterial function
arteriovenous fistula (AVF)
calcitriol
end-stage renal disease (ESRD)
endothelial function
epidemiology
flow mediated dilation (FMD)
hemodialysis
nitroglycerine-mediated dilation (NMD)
pulse wave velocities (PWV)
stiffness
Vascular function
vasodilation
vitamin D metabolites

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1053/j.ajkd.2017.01.049

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van Ballegooijen, A. J., Zelnick, L., Hoofnagle, A. N., Hamburg, N. M., Robinson-Cohen, C., Roy-Chaudhury, P., Cheung, A. K., Shiu, Y. T., de Boer, I. H., Himmelfarb, J., Beck, G., Imrey, P. B., Kusek, J. W., Kestenbaum, B., on behalf of the, & Hemodialysis Fistula Maturation (HFM) Study Group (2017). Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study. American Journal of Kidney Diseases, 69(6), 805-814. https://doi.org/10.1053/j.ajkd.2017.01.049

@article{58a1fde520074a16990b984caa27b68c,

title = "Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study",

abstract = "Background Disturbances in vitamin D metabolism are common in patients with end-stage renal disease and may contribute to vascular dysfunction. Study Design Cross-sectional. Setting & Participants We evaluated 558 of 602 participants at baseline of the Hemodialysis Fistula Maturation (HFM) Study, a 7-center prospective cohort study of a cohort of patients with chronic kidney disease awaiting arteriovenous fistula (AVF) creation surgery. Factor 4 vitamin D metabolites measured with liquid chromatography–tandem mass spectroscopy from samples obtained within 4 weeks prior to AVF surgery. Outcomes Vasodilator functions and measurements of arterial stiffness. Measurements Trained HFM Study personnel measured brachial artery flow-mediated dilation, nitroglycerin-mediated dilation, and carotid-femoral and carotid-radial pulse wave velocities (PWVs) prior to AVF creation. We evaluated associations after basic adjustment for sex, age, and clinical site and more fully adjusted additionally for baseline education, smoking, body mass index, diabetes, dialysis status, and medication use. Results Mean participant age was 55 ± 13 (SD) years and 65% were receiving maintenance dialysis. None of the vitamin D metabolites were significantly associated with flow-mediated dilation, carotid-femoral PWV, or carotid-radial PWV in basic or fully adjusted analyses. Higher serum concentrations of bioavailable vitamin D and 1,25-dihydroxyvitamin D were associated with 0.62% and 0.58% greater nitroglycerin-mediated dilation values, respectively, in basic models; however, these associations were no longer statistically significant with full adjustment. There were no significant associations of vitamin D metabolites with carotid-femoral or carotid-radial PWV in fully adjusted analyses. Limitations Cross-sectional ascertainment of vitamin D metabolites and vascular functions late during the course of kidney disease. Conclusions Serum concentrations of vitamin D metabolites are not associated with vasodilator functions or vascular stiffness at baseline in a cohort study of patients with chronic kidney disease awaiting AVF creation surgery. Laboratory measurements of vitamin D metabolites are unlikely to provide useful information regarding vascular functions in this setting.",

keywords = "arterial function, arteriovenous fistula (AVF), calcitriol, end-stage renal disease (ESRD), endothelial function, epidemiology, flow mediated dilation (FMD), hemodialysis, nitroglycerine-mediated dilation (NMD), pulse wave velocities (PWV), stiffness, Vascular function, vasodilation, vitamin D metabolites",

author = "{van Ballegooijen}, {Adriana J.} and Leila Zelnick and Hoofnagle, {Andrew N.} and Hamburg, {Naomi M.} and Cassiane Robinson-Cohen and Prabir Roy-Chaudhury and Cheung, {Alfred K.} and Shiu, {Yan Ting} and {de Boer}, {Ian H.} and Jonathan Himmelfarb and Gerald Beck and Imrey, {Peter B.} and Kusek, {John W.} and Bryan Kestenbaum and {on behalf of the} and {Hemodialysis Fistula Maturation (HFM) Study Group}",

year = "2017",

month = jun,

day = "1",

doi = "10.1053/j.ajkd.2017.01.049",

language = "English",

volume = "69",

pages = "805--814",

journal = "American Journal of Kidney Diseases",

issn = "0272-6386",

publisher = "W.B. Saunders Ltd",

number = "6",

}

van Ballegooijen, AJ, Zelnick, L, Hoofnagle, AN, Hamburg, NM, Robinson-Cohen, C, Roy-Chaudhury, P, Cheung, AK, Shiu, YT, de Boer, IH, Himmelfarb, J, Beck, G, Imrey, PB, Kusek, JW, Kestenbaum, B, on behalf of the & Hemodialysis Fistula Maturation (HFM) Study Group 2017, 'Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study', American Journal of Kidney Diseases, vol. 69, no. 6, pp. 805-814. https://doi.org/10.1053/j.ajkd.2017.01.049

TY - JOUR

T1 - Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study

AU - van Ballegooijen, Adriana J.

AU - Zelnick, Leila

AU - Hoofnagle, Andrew N.

AU - Hamburg, Naomi M.

AU - Robinson-Cohen, Cassiane

AU - Roy-Chaudhury, Prabir

AU - Cheung, Alfred K.

AU - Shiu, Yan Ting

AU - de Boer, Ian H.

AU - Himmelfarb, Jonathan

AU - Beck, Gerald

AU - Imrey, Peter B.

AU - Kusek, John W.

AU - Kestenbaum, Bryan

AU - on behalf of the

AU - Hemodialysis Fistula Maturation (HFM) Study Group

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background Disturbances in vitamin D metabolism are common in patients with end-stage renal disease and may contribute to vascular dysfunction. Study Design Cross-sectional. Setting & Participants We evaluated 558 of 602 participants at baseline of the Hemodialysis Fistula Maturation (HFM) Study, a 7-center prospective cohort study of a cohort of patients with chronic kidney disease awaiting arteriovenous fistula (AVF) creation surgery. Factor 4 vitamin D metabolites measured with liquid chromatography–tandem mass spectroscopy from samples obtained within 4 weeks prior to AVF surgery. Outcomes Vasodilator functions and measurements of arterial stiffness. Measurements Trained HFM Study personnel measured brachial artery flow-mediated dilation, nitroglycerin-mediated dilation, and carotid-femoral and carotid-radial pulse wave velocities (PWVs) prior to AVF creation. We evaluated associations after basic adjustment for sex, age, and clinical site and more fully adjusted additionally for baseline education, smoking, body mass index, diabetes, dialysis status, and medication use. Results Mean participant age was 55 ± 13 (SD) years and 65% were receiving maintenance dialysis. None of the vitamin D metabolites were significantly associated with flow-mediated dilation, carotid-femoral PWV, or carotid-radial PWV in basic or fully adjusted analyses. Higher serum concentrations of bioavailable vitamin D and 1,25-dihydroxyvitamin D were associated with 0.62% and 0.58% greater nitroglycerin-mediated dilation values, respectively, in basic models; however, these associations were no longer statistically significant with full adjustment. There were no significant associations of vitamin D metabolites with carotid-femoral or carotid-radial PWV in fully adjusted analyses. Limitations Cross-sectional ascertainment of vitamin D metabolites and vascular functions late during the course of kidney disease. Conclusions Serum concentrations of vitamin D metabolites are not associated with vasodilator functions or vascular stiffness at baseline in a cohort study of patients with chronic kidney disease awaiting AVF creation surgery. Laboratory measurements of vitamin D metabolites are unlikely to provide useful information regarding vascular functions in this setting.

AB - Background Disturbances in vitamin D metabolism are common in patients with end-stage renal disease and may contribute to vascular dysfunction. Study Design Cross-sectional. Setting & Participants We evaluated 558 of 602 participants at baseline of the Hemodialysis Fistula Maturation (HFM) Study, a 7-center prospective cohort study of a cohort of patients with chronic kidney disease awaiting arteriovenous fistula (AVF) creation surgery. Factor 4 vitamin D metabolites measured with liquid chromatography–tandem mass spectroscopy from samples obtained within 4 weeks prior to AVF surgery. Outcomes Vasodilator functions and measurements of arterial stiffness. Measurements Trained HFM Study personnel measured brachial artery flow-mediated dilation, nitroglycerin-mediated dilation, and carotid-femoral and carotid-radial pulse wave velocities (PWVs) prior to AVF creation. We evaluated associations after basic adjustment for sex, age, and clinical site and more fully adjusted additionally for baseline education, smoking, body mass index, diabetes, dialysis status, and medication use. Results Mean participant age was 55 ± 13 (SD) years and 65% were receiving maintenance dialysis. None of the vitamin D metabolites were significantly associated with flow-mediated dilation, carotid-femoral PWV, or carotid-radial PWV in basic or fully adjusted analyses. Higher serum concentrations of bioavailable vitamin D and 1,25-dihydroxyvitamin D were associated with 0.62% and 0.58% greater nitroglycerin-mediated dilation values, respectively, in basic models; however, these associations were no longer statistically significant with full adjustment. There were no significant associations of vitamin D metabolites with carotid-femoral or carotid-radial PWV in fully adjusted analyses. Limitations Cross-sectional ascertainment of vitamin D metabolites and vascular functions late during the course of kidney disease. Conclusions Serum concentrations of vitamin D metabolites are not associated with vasodilator functions or vascular stiffness at baseline in a cohort study of patients with chronic kidney disease awaiting AVF creation surgery. Laboratory measurements of vitamin D metabolites are unlikely to provide useful information regarding vascular functions in this setting.

KW - arterial function

KW - arteriovenous fistula (AVF)

KW - calcitriol

KW - end-stage renal disease (ESRD)

KW - endothelial function

KW - epidemiology

KW - flow mediated dilation (FMD)

KW - hemodialysis

KW - nitroglycerine-mediated dilation (NMD)

KW - pulse wave velocities (PWV)

KW - stiffness

KW - Vascular function

KW - vasodilation

KW - vitamin D metabolites

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U2 - 10.1053/j.ajkd.2017.01.049

DO - 10.1053/j.ajkd.2017.01.049

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AN - SCOPUS:85016208826

SN - 0272-6386

VL - 69

SP - 805

EP - 814

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

IS - 6

ER -

Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study

Abstract

Funding

Keywords

UN SDGs

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