Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults

E Sillanpää, L Stenroth, A Y Bijlsma, T Rantanen, J S McPhee, T M Maden-Wilkinson, D A Jones, M V Narici, H Gapeyeva, M Pääsuke, Y Barnouin, J-Y Hogrel, G S Butler-Browne, C G M Meskers, A B Maier, T Törmäkangas, S Sipilä

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Pathological obstruction in lungs leads to severe decreases in muscle strength and mobility in patients suffering from chronic obstructive pulmonary disease. The purpose of this study was to investigate the interdependency between muscle strength, spirometric pulmonary functions and mobility outcomes in healthy older men and women, where skeletal muscle and pulmonary function decline without interference of overt disease. A total of 135 69- to 81-year-old participants were recruited into the cross-sectional study, which was performed as a part of European study MyoAge. Full, partial and no mediation models were constructed to assess the interdependency between muscle strength (handgrip strength, knee extension torque, lower extremity muscle power), spirometric pulmonary function (FVC, FEV1 and FEF50) and mobility (6-min walk and Timed Up and Go tests). The models were adjusted for age, sex, total fat mass, body height and site of enrolment. Partial mediation models, indicating both direct and pulmonary function mediated associations between muscle strength and mobility, fitted best to the data. Greater handgrip strength was significantly associated with higher FVC, FEV1 and FEF50 (p < 0.05). Greater muscle power was significantly associated with better performance in mobility tests. Results suggest that decline in mobility with aging may be caused by decreases in both muscle strength and power but also mediated through decreases in spirometric pulmonary function. Future longitudinal studies are warranted to better understand how loss of function and mass of the respiratory muscles will affect pulmonary function among older people and how these changes are linked to mobility decline.

Original languageEnglish
Pages (from-to)9667
JournalAge
Volume36
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Muscle Strength
Lung
Muscles
Respiratory Muscles
Body Height
Torque
Chronic Obstructive Pulmonary Disease
Longitudinal Studies
Lower Extremity
Knee
Skeletal Muscle
Cross-Sectional Studies
Fats

Keywords

  • Aged
  • Aging/physiology
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume/physiology
  • Health Status
  • Healthy Volunteers
  • Humans
  • Life Style
  • Male
  • Motor Activity/physiology
  • Muscle Strength/physiology
  • Prognosis
  • Spirometry/methods
  • Walking/physiology

Cite this

Sillanpää, E., Stenroth, L., Bijlsma, A. Y., Rantanen, T., McPhee, J. S., Maden-Wilkinson, T. M., ... Sipilä, S. (2014). Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults. Age, 36(4), 9667. https://doi.org/10.1007/s11357-014-9667-7
Sillanpää, E ; Stenroth, L ; Bijlsma, A Y ; Rantanen, T ; McPhee, J S ; Maden-Wilkinson, T M ; Jones, D A ; Narici, M V ; Gapeyeva, H ; Pääsuke, M ; Barnouin, Y ; Hogrel, J-Y ; Butler-Browne, G S ; Meskers, C G M ; Maier, A B ; Törmäkangas, T ; Sipilä, S. / Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults. In: Age. 2014 ; Vol. 36, No. 4. pp. 9667.
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abstract = "Pathological obstruction in lungs leads to severe decreases in muscle strength and mobility in patients suffering from chronic obstructive pulmonary disease. The purpose of this study was to investigate the interdependency between muscle strength, spirometric pulmonary functions and mobility outcomes in healthy older men and women, where skeletal muscle and pulmonary function decline without interference of overt disease. A total of 135 69- to 81-year-old participants were recruited into the cross-sectional study, which was performed as a part of European study MyoAge. Full, partial and no mediation models were constructed to assess the interdependency between muscle strength (handgrip strength, knee extension torque, lower extremity muscle power), spirometric pulmonary function (FVC, FEV1 and FEF50) and mobility (6-min walk and Timed Up and Go tests). The models were adjusted for age, sex, total fat mass, body height and site of enrolment. Partial mediation models, indicating both direct and pulmonary function mediated associations between muscle strength and mobility, fitted best to the data. Greater handgrip strength was significantly associated with higher FVC, FEV1 and FEF50 (p < 0.05). Greater muscle power was significantly associated with better performance in mobility tests. Results suggest that decline in mobility with aging may be caused by decreases in both muscle strength and power but also mediated through decreases in spirometric pulmonary function. Future longitudinal studies are warranted to better understand how loss of function and mass of the respiratory muscles will affect pulmonary function among older people and how these changes are linked to mobility decline.",
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Sillanpää, E, Stenroth, L, Bijlsma, AY, Rantanen, T, McPhee, JS, Maden-Wilkinson, TM, Jones, DA, Narici, MV, Gapeyeva, H, Pääsuke, M, Barnouin, Y, Hogrel, J-Y, Butler-Browne, GS, Meskers, CGM, Maier, AB, Törmäkangas, T & Sipilä, S 2014, 'Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults' Age, vol. 36, no. 4, pp. 9667. https://doi.org/10.1007/s11357-014-9667-7

Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults. / Sillanpää, E; Stenroth, L; Bijlsma, A Y; Rantanen, T; McPhee, J S; Maden-Wilkinson, T M; Jones, D A; Narici, M V; Gapeyeva, H; Pääsuke, M; Barnouin, Y; Hogrel, J-Y; Butler-Browne, G S; Meskers, C G M; Maier, A B; Törmäkangas, T; Sipilä, S.

In: Age, Vol. 36, No. 4, 2014, p. 9667.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults

AU - Sillanpää, E

AU - Stenroth, L

AU - Bijlsma, A Y

AU - Rantanen, T

AU - McPhee, J S

AU - Maden-Wilkinson, T M

AU - Jones, D A

AU - Narici, M V

AU - Gapeyeva, H

AU - Pääsuke, M

AU - Barnouin, Y

AU - Hogrel, J-Y

AU - Butler-Browne, G S

AU - Meskers, C G M

AU - Maier, A B

AU - Törmäkangas, T

AU - Sipilä, S

PY - 2014

Y1 - 2014

N2 - Pathological obstruction in lungs leads to severe decreases in muscle strength and mobility in patients suffering from chronic obstructive pulmonary disease. The purpose of this study was to investigate the interdependency between muscle strength, spirometric pulmonary functions and mobility outcomes in healthy older men and women, where skeletal muscle and pulmonary function decline without interference of overt disease. A total of 135 69- to 81-year-old participants were recruited into the cross-sectional study, which was performed as a part of European study MyoAge. Full, partial and no mediation models were constructed to assess the interdependency between muscle strength (handgrip strength, knee extension torque, lower extremity muscle power), spirometric pulmonary function (FVC, FEV1 and FEF50) and mobility (6-min walk and Timed Up and Go tests). The models were adjusted for age, sex, total fat mass, body height and site of enrolment. Partial mediation models, indicating both direct and pulmonary function mediated associations between muscle strength and mobility, fitted best to the data. Greater handgrip strength was significantly associated with higher FVC, FEV1 and FEF50 (p < 0.05). Greater muscle power was significantly associated with better performance in mobility tests. Results suggest that decline in mobility with aging may be caused by decreases in both muscle strength and power but also mediated through decreases in spirometric pulmonary function. Future longitudinal studies are warranted to better understand how loss of function and mass of the respiratory muscles will affect pulmonary function among older people and how these changes are linked to mobility decline.

AB - Pathological obstruction in lungs leads to severe decreases in muscle strength and mobility in patients suffering from chronic obstructive pulmonary disease. The purpose of this study was to investigate the interdependency between muscle strength, spirometric pulmonary functions and mobility outcomes in healthy older men and women, where skeletal muscle and pulmonary function decline without interference of overt disease. A total of 135 69- to 81-year-old participants were recruited into the cross-sectional study, which was performed as a part of European study MyoAge. Full, partial and no mediation models were constructed to assess the interdependency between muscle strength (handgrip strength, knee extension torque, lower extremity muscle power), spirometric pulmonary function (FVC, FEV1 and FEF50) and mobility (6-min walk and Timed Up and Go tests). The models were adjusted for age, sex, total fat mass, body height and site of enrolment. Partial mediation models, indicating both direct and pulmonary function mediated associations between muscle strength and mobility, fitted best to the data. Greater handgrip strength was significantly associated with higher FVC, FEV1 and FEF50 (p < 0.05). Greater muscle power was significantly associated with better performance in mobility tests. Results suggest that decline in mobility with aging may be caused by decreases in both muscle strength and power but also mediated through decreases in spirometric pulmonary function. Future longitudinal studies are warranted to better understand how loss of function and mass of the respiratory muscles will affect pulmonary function among older people and how these changes are linked to mobility decline.

KW - Aged

KW - Aging/physiology

KW - Cross-Sectional Studies

KW - Female

KW - Follow-Up Studies

KW - Forced Expiratory Volume/physiology

KW - Health Status

KW - Healthy Volunteers

KW - Humans

KW - Life Style

KW - Male

KW - Motor Activity/physiology

KW - Muscle Strength/physiology

KW - Prognosis

KW - Spirometry/methods

KW - Walking/physiology

U2 - 10.1007/s11357-014-9667-7

DO - 10.1007/s11357-014-9667-7

M3 - Article

VL - 36

SP - 9667

JO - Age

JF - Age

SN - 0161-9152

IS - 4

ER -

Sillanpää E, Stenroth L, Bijlsma AY, Rantanen T, McPhee JS, Maden-Wilkinson TM et al. Associations between muscle strength, spirometric pulmonary function and mobility in healthy older adults. Age. 2014;36(4):9667. https://doi.org/10.1007/s11357-014-9667-7