Associations between Oxytocin Receptor (OXTR) Genotype and Elementary School Children’s Likability, Dis-likability and Friendship among Classroom Peers: A Longitudinal Study

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The single nucleotide polymorphism rs53576 of the oxytocin receptor (OXTR) gene is involved in forming and maintaining relationships in various social contexts. However, this has not been studied in the childhood peer context. The present study followed 359 children (51.6% girls) from age 9 to 12 to explore associations between OXTR rs53576 genotype (i.e., AA, AG or GG genotype) and three indicators of children’s relationships with peers: likability and dis-likability among, and friendship with, classroom peers. Our results showed that OXTR rs53576 was associated with likability among boys, but not with dis-likability and friendship or among girls. Boys with an A and a G allele (i.e., AG genotype) became increasingly more liked by their peers across the four-year studied period than those with two A alleles or two G alleles (i.e., AA and GG genotype). This study indicates that OXTR rs53576 genotype might influence children’s peer relationships, particularly their likeability among peers. Associations between OXTR rs53576 and peer relationships may differ depending on children’s sex and the specific type of peer-relationship under scrutiny.

LanguageEnglish
Pages1-14
Number of pages14
JournalJournal of Youth and Adolescence
DOIs
Publication statusAccepted/In press - 27 Apr 2018

Fingerprint

Oxytocin Receptors
schoolchild
friendship
elementary school
Longitudinal Studies
longitudinal study
Genotype
classroom
Alleles
childhood
Single Nucleotide Polymorphism
Genes

Keywords

  • Children
  • Longitudinal design
  • Oxytocin receptor gene
  • Peer relationships
  • Rs53576

Cite this

@article{113cd59cdb394f5985a4b173faeadcb9,
title = "Associations between Oxytocin Receptor (OXTR) Genotype and Elementary School Children’s Likability, Dis-likability and Friendship among Classroom Peers: A Longitudinal Study",
abstract = "The single nucleotide polymorphism rs53576 of the oxytocin receptor (OXTR) gene is involved in forming and maintaining relationships in various social contexts. However, this has not been studied in the childhood peer context. The present study followed 359 children (51.6{\%} girls) from age 9 to 12 to explore associations between OXTR rs53576 genotype (i.e., AA, AG or GG genotype) and three indicators of children’s relationships with peers: likability and dis-likability among, and friendship with, classroom peers. Our results showed that OXTR rs53576 was associated with likability among boys, but not with dis-likability and friendship or among girls. Boys with an A and a G allele (i.e., AG genotype) became increasingly more liked by their peers across the four-year studied period than those with two A alleles or two G alleles (i.e., AA and GG genotype). This study indicates that OXTR rs53576 genotype might influence children’s peer relationships, particularly their likeability among peers. Associations between OXTR rs53576 and peer relationships may differ depending on children’s sex and the specific type of peer-relationship under scrutiny.",
keywords = "Children, Longitudinal design, Oxytocin receptor gene, Peer relationships, Rs53576",
author = "Jin He and Buil, {J. Marieke} and Koot, {Hans M.} and {van Lier}, {Pol A.C.}",
year = "2018",
month = "4",
day = "27",
doi = "10.1007/s10964-018-0855-0",
language = "English",
pages = "1--14",
journal = "Journal of Youth and Adolescence",
issn = "0047-2891",
publisher = "Springer New York",

}

TY - JOUR

T1 - Associations between Oxytocin Receptor (OXTR) Genotype and Elementary School Children’s Likability, Dis-likability and Friendship among Classroom Peers

T2 - Journal of Youth and Adolescence

AU - He, Jin

AU - Buil, J. Marieke

AU - Koot, Hans M.

AU - van Lier, Pol A.C.

PY - 2018/4/27

Y1 - 2018/4/27

N2 - The single nucleotide polymorphism rs53576 of the oxytocin receptor (OXTR) gene is involved in forming and maintaining relationships in various social contexts. However, this has not been studied in the childhood peer context. The present study followed 359 children (51.6% girls) from age 9 to 12 to explore associations between OXTR rs53576 genotype (i.e., AA, AG or GG genotype) and three indicators of children’s relationships with peers: likability and dis-likability among, and friendship with, classroom peers. Our results showed that OXTR rs53576 was associated with likability among boys, but not with dis-likability and friendship or among girls. Boys with an A and a G allele (i.e., AG genotype) became increasingly more liked by their peers across the four-year studied period than those with two A alleles or two G alleles (i.e., AA and GG genotype). This study indicates that OXTR rs53576 genotype might influence children’s peer relationships, particularly their likeability among peers. Associations between OXTR rs53576 and peer relationships may differ depending on children’s sex and the specific type of peer-relationship under scrutiny.

AB - The single nucleotide polymorphism rs53576 of the oxytocin receptor (OXTR) gene is involved in forming and maintaining relationships in various social contexts. However, this has not been studied in the childhood peer context. The present study followed 359 children (51.6% girls) from age 9 to 12 to explore associations between OXTR rs53576 genotype (i.e., AA, AG or GG genotype) and three indicators of children’s relationships with peers: likability and dis-likability among, and friendship with, classroom peers. Our results showed that OXTR rs53576 was associated with likability among boys, but not with dis-likability and friendship or among girls. Boys with an A and a G allele (i.e., AG genotype) became increasingly more liked by their peers across the four-year studied period than those with two A alleles or two G alleles (i.e., AA and GG genotype). This study indicates that OXTR rs53576 genotype might influence children’s peer relationships, particularly their likeability among peers. Associations between OXTR rs53576 and peer relationships may differ depending on children’s sex and the specific type of peer-relationship under scrutiny.

KW - Children

KW - Longitudinal design

KW - Oxytocin receptor gene

KW - Peer relationships

KW - Rs53576

UR - http://www.scopus.com/inward/record.url?scp=85046021606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046021606&partnerID=8YFLogxK

U2 - 10.1007/s10964-018-0855-0

DO - 10.1007/s10964-018-0855-0

M3 - Article

SP - 1

EP - 14

JO - Journal of Youth and Adolescence

JF - Journal of Youth and Adolescence

SN - 0047-2891

ER -