Abstract
The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.
| Original language | English |
|---|---|
| Journal | The journals of gerontology. Series A, Biological sciences and medical sciences |
| DOIs | |
| Publication status | E-pub ahead of print - 14 Aug 2019 |
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Bibliographical note
© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.Cite this
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Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years. / Legdeur, Nienke; Tijms, Betty M; Konijnenberg, Elles; den Braber, Anouk; Ten Kate, Mara; Sudre, Carole H; Tomassen, Jori; Badissi, Maryam; Yaqub, Maqsood; Barkhof, Frederik; van Berckel, Bart N; Boomsma, Dorret I; Scheltens, Philip; Holstege, Henne; Maier, Andrea B; Visser, Pieter Jelle.
In: The journals of gerontology. Series A, Biological sciences and medical sciences, 14.08.2019.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years
AU - Legdeur, Nienke
AU - Tijms, Betty M
AU - Konijnenberg, Elles
AU - den Braber, Anouk
AU - Ten Kate, Mara
AU - Sudre, Carole H
AU - Tomassen, Jori
AU - Badissi, Maryam
AU - Yaqub, Maqsood
AU - Barkhof, Frederik
AU - van Berckel, Bart N
AU - Boomsma, Dorret I
AU - Scheltens, Philip
AU - Holstege, Henne
AU - Maier, Andrea B
AU - Visser, Pieter Jelle
N1 - © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2019/8/14
Y1 - 2019/8/14
N2 - The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.
AB - The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.
U2 - 10.1093/gerona/glz180
DO - 10.1093/gerona/glz180
M3 - Article
JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
SN - 1079-5006
ER -