Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies

InterAct Consortium

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.

Original languageEnglish
Pages (from-to)1216-1223
Number of pages8
JournalThe American journal of clinical nutrition
Volume109
Issue number4
Early online date15 Apr 2019
DOIs
Publication statusPublished - Apr 2019

Fingerprint

Type 2 Diabetes Mellitus
Cohort Studies
Fatty Acids
Prospective Studies
Adiposity
Meta-Analysis
Life Style
Triglycerides
Logistic Models
Demography
Outcome Assessment (Health Care)
Health
Population
lignoceric acid
behenic acid
arachidic acid

Keywords

  • Cohorts for Heart and Aging Research in Genomic Epidemiology
  • diabetes
  • Fatty Acids and Outcomes Research Consortium
  • meta-analysis
  • saturated fatty acids
  • very-long-chain saturated fatty acids

Cite this

@article{02c70c2f2fd84702a8dccf15788bed7c,
title = "Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies",
abstract = "BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95{\%} CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.",
keywords = "Cohorts for Heart and Aging Research in Genomic Epidemiology, diabetes, Fatty Acids and Outcomes Research Consortium, meta-analysis, saturated fatty acids, very-long-chain saturated fatty acids",
author = "Fretts, {Amanda M.} and Fumiaki Imamura and Matti Marklund and Renata Micha and Wu, {Jason H.Y.} and Murphy, {Rachel A.} and Chien, {Kuo Liong} and Barbara McKnight and Nathan Tintle and Forouhi, {Nita G.} and Qureshi, {Waqas T.} and Virtanen, {Jyrki K.} and Kerry Wong and Wood, {Alexis C.} and Maria Lankinen and Kalina Rajaobelina and Harris, {Tamara B.} and Luc Djouss{\'e} and Bill Harris and Wareham, {Nick J.} and Steffen, {Lyn M.} and Markku Laakso and Jenna Veenstra and C{\'e}cilia Samieri and Brouwer, {Ingeborg A.} and Yu, {Chaoyu Ian} and Albert Koulman and Steffen, {Brian T.} and Catherine Helmer and Nona Sotoodehnia and David Siscovick and Vilmundur Gudnason and Lynne Wagenknecht and Sari Voutilainen and Tsai, {Michael Y.} and Matti Uusitupa and Anya Kalsbeek and Claudine Berr and Dariush Mozaffarian and Lemaitre, {Rozenn N.} and {InterAct Consortium}",
year = "2019",
month = "4",
doi = "10.1093/ajcn/nqz005",
language = "English",
volume = "109",
pages = "1216--1223",
journal = "The American journal of clinical nutrition",
issn = "1938-3207",
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Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes : a pooled analysis of prospective cohort studies. / InterAct Consortium.

In: The American journal of clinical nutrition, Vol. 109, No. 4, 04.2019, p. 1216-1223.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes

T2 - a pooled analysis of prospective cohort studies

AU - Fretts, Amanda M.

AU - Imamura, Fumiaki

AU - Marklund, Matti

AU - Micha, Renata

AU - Wu, Jason H.Y.

AU - Murphy, Rachel A.

AU - Chien, Kuo Liong

AU - McKnight, Barbara

AU - Tintle, Nathan

AU - Forouhi, Nita G.

AU - Qureshi, Waqas T.

AU - Virtanen, Jyrki K.

AU - Wong, Kerry

AU - Wood, Alexis C.

AU - Lankinen, Maria

AU - Rajaobelina, Kalina

AU - Harris, Tamara B.

AU - Djoussé, Luc

AU - Harris, Bill

AU - Wareham, Nick J.

AU - Steffen, Lyn M.

AU - Laakso, Markku

AU - Veenstra, Jenna

AU - Samieri, Cécilia

AU - Brouwer, Ingeborg A.

AU - Yu, Chaoyu Ian

AU - Koulman, Albert

AU - Steffen, Brian T.

AU - Helmer, Catherine

AU - Sotoodehnia, Nona

AU - Siscovick, David

AU - Gudnason, Vilmundur

AU - Wagenknecht, Lynne

AU - Voutilainen, Sari

AU - Tsai, Michael Y.

AU - Uusitupa, Matti

AU - Kalsbeek, Anya

AU - Berr, Claudine

AU - Mozaffarian, Dariush

AU - Lemaitre, Rozenn N.

AU - InterAct Consortium

PY - 2019/4

Y1 - 2019/4

N2 - BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.

AB - BACKGROUND: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed. OBJECTIVE: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. METHODS: Twelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants. RESULTS: There were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides. CONCLUSIONS: Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.

KW - Cohorts for Heart and Aging Research in Genomic Epidemiology

KW - diabetes

KW - Fatty Acids and Outcomes Research Consortium

KW - meta-analysis

KW - saturated fatty acids

KW - very-long-chain saturated fatty acids

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JO - The American journal of clinical nutrition

JF - The American journal of clinical nutrition

SN - 1938-3207

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