Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

Sijia Chen; Graham Pawelec; Stella Trompet; David Goldeck; Laust H. Mortensen; P. Eline Slagboom; Kaare Christensen; Jacobijn Gussekloo; Patricia Kearney; Brendan M. Buckley; Ian Ford; J. Wouter Jukema; Rudi G.J. Westendorp; Andrea B. Maier

doi:10.1093/infdis/jiaa480

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

Sijia Chen
, Graham Pawelec
, Stella Trompet
, David Goldeck
, Laust H. Mortensen
, P. Eline Slagboom
, Kaare Christensen
, Jacobijn Gussekloo
, Patricia Kearney
, Brendan M. Buckley
, Ian Ford
, J. Wouter Jukema
, Rudi G.J. Westendorp
, Andrea B. Maier

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts.

METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders.

RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses.

CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.

Original language	English
Pages (from-to)	238-246
Number of pages	9
Journal	The Journal of infectious diseases
Volume	223
Issue number	2
Early online date	10 Sept 2020
DOIs	https://doi.org/10.1093/infdis/jiaa480
Publication status	Published - 15 Jan 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

Funding

Funders	Funder number
European Commission
National Institute of Allergy and Infectious Diseases	R01AI125498, K01AI116298, P30AI027757
National Institute of Mental Health	K01MH121124
Seventh Framework Programme	259679, 223004
???publication-publication-funding-organisation-not-added???	050-060-810

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

aged
cardiovascular
cytomegalovirus
Herpesviridae
immunoglobulin G
mortality
seroepidemiologic studies

Access to Document

10.1093/infdis/jiaa480

Persistent URL (handle)

Persistent link

Cite this

Chen, S., Pawelec, G., Trompet, S., Goldeck, D., Mortensen, L. H., Slagboom, P. E., Christensen, K., Gussekloo, J., Kearney, P., Buckley, B. M., Ford, I., Jukema, J. W., Westendorp, R. G. J., & Maier, A. B. (2021). Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults. The Journal of infectious diseases, 223(2), 238-246. https://doi.org/10.1093/infdis/jiaa480

@article{7a21cf82c4ee4692b8590d0af48694c6,

title = "Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults",

abstract = "BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts.METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders.RESULTS: CMV-seropositivity was seen in 47\%-79\% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95\% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95\% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95\% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95\% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses.CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.",

keywords = "aged, cardiovascular, cytomegalovirus, Herpesviridae, immunoglobulin G, mortality, seroepidemiologic studies",

author = "Sijia Chen and Graham Pawelec and Stella Trompet and David Goldeck and Mortensen, \{Laust H.\} and Slagboom, \{P. Eline\} and Kaare Christensen and Jacobijn Gussekloo and Patricia Kearney and Buckley, \{Brendan M.\} and Ian Ford and Jukema, \{J. Wouter\} and Westendorp, \{Rudi G.J.\} and Maier, \{Andrea B.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine",

year = "2021",

month = jan,

day = "15",

doi = "10.1093/infdis/jiaa480",

language = "English",

volume = "223",

pages = "238--246",

journal = "The Journal of infectious diseases",

issn = "1537-6613",

publisher = "Oxford University Press",

number = "2",

}

Chen, S, Pawelec, G, Trompet, S, Goldeck, D, Mortensen, LH, Slagboom, PE, Christensen, K, Gussekloo, J, Kearney, P, Buckley, BM, Ford, I, Jukema, JW, Westendorp, RGJ & Maier, AB 2021, 'Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults', The Journal of infectious diseases, vol. 223, no. 2, pp. 238-246. https://doi.org/10.1093/infdis/jiaa480

TY - JOUR

T1 - Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

AU - Chen, Sijia

AU - Pawelec, Graham

AU - Trompet, Stella

AU - Goldeck, David

AU - Mortensen, Laust H.

AU - Slagboom, P. Eline

AU - Christensen, Kaare

AU - Gussekloo, Jacobijn

AU - Kearney, Patricia

AU - Buckley, Brendan M.

AU - Ford, Ian

AU - Jukema, J. Wouter

AU - Westendorp, Rudi G.J.

AU - Maier, Andrea B.

N1 - Publisher Copyright: © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2021/1/15

Y1 - 2021/1/15

N2 - BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts.METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders.RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses.CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.

AB - BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts.METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders.RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses.CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.

KW - aged

KW - cardiovascular

KW - cytomegalovirus

KW - Herpesviridae

KW - immunoglobulin G

KW - mortality

KW - seroepidemiologic studies

UR - https://www.scopus.com/pages/publications/85102099025

UR - https://www.scopus.com/pages/publications/85102099025#tab=citedBy

U2 - 10.1093/infdis/jiaa480

DO - 10.1093/infdis/jiaa480

M3 - Article

C2 - 32909605

AN - SCOPUS:85102099025

SN - 1537-6613

VL - 223

SP - 238

EP - 246

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 2

ER -

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this