TY - JOUR
T1 - Associations of medication with subcortical morphology across the lifespan in OCD
T2 - Results from the international ENIGMA Consortium
AU - Ivanov, Iliyan
AU - Boedhoe, Premika S.W.
AU - Abe, Yoshinari
AU - Alonso, Pino
AU - Ameis, Stephanie H.
AU - Arnold, Paul D.
AU - Balachander, Srinivas
AU - Baker, Justin T.
AU - Banaj, Nerisa
AU - Bargalló, Nuria
AU - Batistuzzo, Marcelo C.
AU - Benedetti, Francesco
AU - Beucke, Jan C.
AU - Bollettini, Irene
AU - Brem, Silvia
AU - Brennan, Brian P.
AU - Buitelaar, Jan
AU - Calvo, Rosa
AU - Cheng, Yuqi
AU - Cho, Kang Ik K.
AU - Dallaspezia, Sara
AU - Denys, Damiaan
AU - Diniz, Juliana B.
AU - Ely, Benjamin A.
AU - Feusner, Jamie D.
AU - Ferreira, Sónia
AU - Fitzgerald, Kate D.
AU - Fontaine, Martine
AU - Gruner, Patricia
AU - Hanna, Gregory L.
AU - Hirano, Yoshiyuki
AU - Hoexter, Marcelo Q.
AU - Huyser, Chaim
AU - Ikari, Keisuke
AU - James, Anthony
AU - Jaspers-Fayer, Fern
AU - Jiang, Hongyan
AU - Kathmann, Norbert
AU - Kaufmann, Christian
AU - Kim, Minah
AU - Koch, Kathrin
AU - Kwon, Jun Soo
AU - Lázaro, Luisa
AU - Liu, Yanni
AU - Lochner, Christine
AU - Marsh, Rachel
AU - Martínez-Zalacaín, Ignacio
AU - Mataix-Cols, David
AU - Menchón, José M.
AU - Minuzzi, Luciano
AU - Morer, Astrid
AU - Morgado, Pedro
AU - Nakagawa, Akiko
AU - Nakamae, Takashi
AU - Nakao, Tomohiro
AU - Narayanaswamy, Janardhanan C.
AU - Nurmi, Erika L.
AU - Oh, Sanghoon
AU - Perriello, Chris
AU - Piacentini, John C.
AU - Picó-Pérez, Maria
AU - Piras, Fabrizio
AU - Piras, Federica
AU - Reddy, Y.C. Janardhan
AU - Manrique, Daniela Rodriguez
AU - Sakai, Yuki
AU - Shimizu, Eiji
AU - Simpson, H. Blair
AU - Soreni, Noam
AU - Soriano-Mas, Carles
AU - Spalletta, Gianfranco
AU - Stern, Emily R.
AU - Stevens, Michael C.
AU - Stewart, S. Evelyn
AU - Szeszko, Philip R.
AU - Tolin, David F.
AU - van Rooij, Daan
AU - Veltman, Dick J.
AU - van der Werf, Ysbrand D.
AU - van Wingen, Guido A.
AU - Venkatasubramanian, Ganesan
AU - Walitza, Susanne
AU - Wang, Zhen
AU - Watanabe, Anri
AU - Wolters, Lidewij H.
AU - Xu, Xiufeng
AU - Yun, Je-Yeon
AU - Zarei, Mojtaba
AU - Zhang, Fengrui
AU - Zhao, Qing
AU - Jahanshad, Neda
AU - Thomopoulos, Sophia I.
AU - Thompson, Paul M.
AU - Stein, Dan J.
AU - van den Heuvel, Odile A.
AU - O'Neill, Joseph
AU - Poletti, Sara
AU - Fridgeirsson, Egill Axfjord
AU - Ikuta, Toshikazu
AU - de Wit, Stella J.
AU - Vriend, Chris
AU - Kasprzak, Selina
AU - Kuno, Masaru
AU - Takahashi, Jumpei
AU - Miguel, Euripedes C.
AU - Shavitt, Roseli G.
AU - Hough, Morgan
AU - Pariente, Jose C.
AU - Ortiz, Ana E.
AU - Bertolín, Sara
AU - Real, Eva
AU - Segalàs, Cinto
AU - Moreira, Pedro Silva
AU - Sousa, Nuno
AU - Narumoto, Jin
AU - Yamada, Kei
AU - Tang, Jinsong
AU - Fouche, Jean-Paul
AU - Kim, Taekwan
AU - Choi, Sunah
AU - Ha, Minji
AU - Park, Sunghyun
AU - the ENIGMA-OCD Working Group
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. Methods: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6–65) was divided into six successive 6–10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients. Results: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6–13 and adults aged 50–65 with OCD taking SRIs (Cohen's d = −0.24 to −0.74). Volumes of putamen, pallidum (d = 0.18–0.40), and ventricles (d = 0.31–0.66) were greater in patients aged 20–29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = −0.27 to −1.31). Conclusions: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20–29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.
AB - Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. Methods: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6–65) was divided into six successive 6–10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients. Results: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6–13 and adults aged 50–65 with OCD taking SRIs (Cohen's d = −0.24 to −0.74). Volumes of putamen, pallidum (d = 0.18–0.40), and ventricles (d = 0.31–0.66) were greater in patients aged 20–29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = −0.27 to −1.31). Conclusions: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20–29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.
UR - https://www.scopus.com/pages/publications/85137704230
U2 - 10.1016/j.jad.2022.08.084
DO - 10.1016/j.jad.2022.08.084
M3 - Article
SN - 0165-0327
VL - 318
SP - 204
EP - 216
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -