Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults

K.S. Fluitman; T.J. van den Broek; M. Nieuwdorp; M. Visser; R.G. IJzerman; B.J.F. Keijser

doi:10.1038/s41598-021-02558-8

Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults

K.S. Fluitman, T.J. van den Broek, M. Nieuwdorp, M. Visser, R.G. IJzerman, B.J.F. Keijser

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

© 2021, The Author(s).Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric measurements and tongue swabs for analysis of microbial composition (16S rRNA sequencing) and Candida albicans abundance (qPCR). Older age, edentation, poor smell and poor appetite were associated with lower alpha diversity and explained a significant amount of beta diversity. Moreover, a lower Streptococcus salivarius abundance was associated with poor smell identification score, whereas high C. albicans abundance seemed to be associated with poor smell discrimination score. In our population, neither the tongue microbiota, nor C. albicans were associated with poor taste or directly with undernutrition. Our findings do suggest a host-microbe interaction with regard to smell perception and appetite.

Original language	English
Article number	23254
Journal	Scientific Reports
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41598-021-02558-8
Publication status	Published - 1 Dec 2021

Funding

This study was supported by the European Union Horizon 2020 PROMISS Project ‘PRevention Of Malnutrition In Senior Subjects in the EU’ (Grant Agreement No. 678732). The content only reflects the author’s view and the Commission is not responsible for any use that may be made of the information it contains. The Longitudinal Aging Study Amsterdam is supported by a grant from the Netherlands Ministry of Health Welfare and Sports, Directorate of Long-Term Care. The LASA data collection in 2012–2013 was financially supported by the Netherlands Organization for Scientific Research (NWO) in the framework of the project “New Cohorts of young old in the twenty-first century” (File Number 480-10-014).

Funders	Funder number
Netherlands Ministry of Health Welfare and Sports, Directorate of Long-Term Care
Horizon 2020 Framework Programme	678732
European Commission
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Horizon 2020
Aard- en Levenswetenschappen, Nederlandse Organisatie voor Wetenschappelijk Onderzoek	480-10-014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "{\textcopyright} 2021, The Author(s).Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric measurements and tongue swabs for analysis of microbial composition (16S rRNA sequencing) and Candida albicans abundance (qPCR). Older age, edentation, poor smell and poor appetite were associated with lower alpha diversity and explained a significant amount of beta diversity. Moreover, a lower Streptococcus salivarius abundance was associated with poor smell identification score, whereas high C. albicans abundance seemed to be associated with poor smell discrimination score. In our population, neither the tongue microbiota, nor C. albicans were associated with poor taste or directly with undernutrition. Our findings do suggest a host-microbe interaction with regard to smell perception and appetite.",

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AU - Nieuwdorp, M.

AU - Visser, M.

AU - IJzerman, R.G.

AU - Keijser, B.J.F.

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AB - © 2021, The Author(s).Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric measurements and tongue swabs for analysis of microbial composition (16S rRNA sequencing) and Candida albicans abundance (qPCR). Older age, edentation, poor smell and poor appetite were associated with lower alpha diversity and explained a significant amount of beta diversity. Moreover, a lower Streptococcus salivarius abundance was associated with poor smell identification score, whereas high C. albicans abundance seemed to be associated with poor smell discrimination score. In our population, neither the tongue microbiota, nor C. albicans were associated with poor taste or directly with undernutrition. Our findings do suggest a host-microbe interaction with regard to smell perception and appetite.

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Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults

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UN SDGs

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