Abstract
We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds.
Original language | English |
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Pages (from-to) | 7706-7708 |
Number of pages | 3 |
Journal | Chemical Commununications |
Volume | 46 |
Issue number | 41 |
Early online date | 27 Sept 2010 |
DOIs | |
Publication status | Published - 7 Nov 2010 |
Keywords
- Alkaloids/biosynthesis
- Aspergillus niger/enzymology
- Biocatalysis
- Cyclization
- Monoamine Oxidase/metabolism
- Oxidation-Reduction
- Stereoisomerism
- Substrate Specificity
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CCDC 786098: Experimental Crystal Structure Determination
Znabet, A. (Contributor), Zonneveld, J. (Contributor), Janssen, E. (Contributor), De Kanter, F. J. J. (Contributor), Helliwell, M. (Contributor), Turner, N. J. (Contributor), Ruijter, E. (Contributor) & Orru, R. V. A. (Contributor), Unknown Publisher, 1 Jan 2011
DOI: 10.5517/ccvd007, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccvd007&sid=DataCite
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