We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds.
- Aspergillus niger/enzymology
- Monoamine Oxidase/metabolism
- Substrate Specificity
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Znabet, A. (Contributor), Zonneveld, J. (Contributor), Janssen, E. (Contributor), De Kanter, F. J. J. (Contributor), Helliwell, M. (Contributor), Turner, N. J. (Contributor), Ruijter, E. (Contributor) & Orru, R. V. A. (Contributor), Unknown Publisher, 1 Jan 2011