Atrophy in non-locomotor muscle in patients with end-stage renal failure

G.K. Sakkas, D. Ball, T.H. Mercer, A.J. Sargeant, K. Tolfrey, P.F. Naish

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    Abstract

    Background. All previous histological studies of skeletal muscles of patients with renal failure have used locomotor muscle biopsies. It is thus unclear to what degree the observed abnormalities are due to the uraemic state and how much is due to disuse. The present study was undertaken to attempt to investigate this question by examining a non-locomotor muscle (rectus abdominis) in patients with end-stage renal failure. Methods. Biopsies from rectus abdominis were obtained from 22 renal failure patients (RFPs) undergoing surgical Tenchkoff catheter implantation for peritoneal dialysis and 20 control subjects undergoing elective abdominal surgery. Histochemical staining of frozen sections and morphometric analysis was used to estimate the proportion of each fibre type, muscle fibre area and capillary density. Myosin heavy chain composition was examined by SDS-PAGE. Results. There were no differences in fibre type distribution between RFPs and controls. All RFPs showed fibre atrophy [mean cross-sectional area (CSA) 3300 ± 1100 μm
    Original languageEnglish
    Pages (from-to)2074-2081
    JournalNephrology, Dialysis, Transplantation
    Volume18
    DOIs
    Publication statusPublished - 2003

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