Attention deficit hyperactivity disorder and autism spectrum disorder symptoms in school-age children born very preterm

Tinka Bröring, Kim J. Oostrom, Elisabeth M. van Dijk-Lokkart, Harrie N. Lafeber, Anniek Brugman, Jaap Oosterlaan

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Very preterm (VP) children face a broad range of neurodevelopmental sequelae, including behavioral problems. Aim: To investigate prevalence, pervasiveness and co-occurrence of symptoms of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in school-age children born very preterm. Methods: Using questionnaire and diagnostic interview data, parent and teacher reported symptoms of ADHD and ASD of 57 VP-children (mean age = 9.2 years) were compared with 57 gender and age matched full-term children using t-tests. Intra-class correlation coefficients quantified parent-teacher agreement. Correlation analysis investigated co-occurrence of ADHD/ASD symptoms. ADHD/ASD measures were aggregated using principal component analysis. Regression analyses investigated the contribution of perinatal risk factors, sex and SES to ADHD/ASD symptoms. Results: VP-children showed higher levels of parent and teacher reported attention problems, social impairment and compromised communication skills. Fair to strong agreement was found between parent and teacher reported ADHD and ASD symptoms, indicating pervasiveness of observed difficulties. Co-occurrence of ADHD and ASD symptoms in VP-children was found. Lower gestational age was associated with higher ADHD and ASD symptom levels, male sex with higher ADHD symptom levels and lower SES with higher ASD symptom levels. Conclusion: School-age VP-children show higher levels of ADHD and ASD symptoms, and attention, socialization and communication difficulties in particular. Routinely screening for these problems is recommended in follow-up care.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalResearch in Developmental Disabilities
Volume74
Issue numberMarch
Early online date2 Feb 2018
DOIs
Publication statusPublished - Mar 2018

Fingerprint

Attention Deficit Disorder with Hyperactivity
Communication
Autism Spectrum Disorder
Aftercare
Socialization
Social Problems
Principal Component Analysis
Gestational Age
Regression Analysis
Interviews

Keywords

  • ADHD
  • ASD
  • Behavior
  • Neurodevelopment
  • Prematurity

Cite this

Bröring, Tinka ; Oostrom, Kim J. ; van Dijk-Lokkart, Elisabeth M. ; Lafeber, Harrie N. ; Brugman, Anniek ; Oosterlaan, Jaap. / Attention deficit hyperactivity disorder and autism spectrum disorder symptoms in school-age children born very preterm. In: Research in Developmental Disabilities. 2018 ; Vol. 74, No. March. pp. 103-112.
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Attention deficit hyperactivity disorder and autism spectrum disorder symptoms in school-age children born very preterm. / Bröring, Tinka; Oostrom, Kim J.; van Dijk-Lokkart, Elisabeth M.; Lafeber, Harrie N.; Brugman, Anniek; Oosterlaan, Jaap.

In: Research in Developmental Disabilities, Vol. 74, No. March, 03.2018, p. 103-112.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Lafeber, Harrie N.

AU - Brugman, Anniek

AU - Oosterlaan, Jaap

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AB - Background: Very preterm (VP) children face a broad range of neurodevelopmental sequelae, including behavioral problems. Aim: To investigate prevalence, pervasiveness and co-occurrence of symptoms of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in school-age children born very preterm. Methods: Using questionnaire and diagnostic interview data, parent and teacher reported symptoms of ADHD and ASD of 57 VP-children (mean age = 9.2 years) were compared with 57 gender and age matched full-term children using t-tests. Intra-class correlation coefficients quantified parent-teacher agreement. Correlation analysis investigated co-occurrence of ADHD/ASD symptoms. ADHD/ASD measures were aggregated using principal component analysis. Regression analyses investigated the contribution of perinatal risk factors, sex and SES to ADHD/ASD symptoms. Results: VP-children showed higher levels of parent and teacher reported attention problems, social impairment and compromised communication skills. Fair to strong agreement was found between parent and teacher reported ADHD and ASD symptoms, indicating pervasiveness of observed difficulties. Co-occurrence of ADHD and ASD symptoms in VP-children was found. Lower gestational age was associated with higher ADHD and ASD symptom levels, male sex with higher ADHD symptom levels and lower SES with higher ASD symptom levels. Conclusion: School-age VP-children show higher levels of ADHD and ASD symptoms, and attention, socialization and communication difficulties in particular. Routinely screening for these problems is recommended in follow-up care.

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