TY - JOUR
T1 - Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children
AU - Blokhuis, M.M.
AU - Middeldorp, C.M.
AU - Kan, K.J.
AU - Abdellaoui, A.
AU - van Beijsterveldt, C.E.M.
AU - Ehli, E.A.
AU - Davies, G.E.
AU - Scheet, P.
AU - Xiao, X.
AU - Hudziak, J.J.
AU - Hottenga, J.J.
AU - Neale, B.M.
AU - Boomsma, D.I.
PY - 2014
Y1 - 2014
N2 - Objective: Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuous distribution of inattentive and hyperactive behaviors. This hypothesis can be tested by assessing the predictive value of polygenic risk scores derived from a discovery sample of ADHD patients in a target sample from the general population with continuous scores of inattention and hyperactivity. In addition, the genetic overlap between ADHD and continuous ADHD scores can be tested across rater and age.
AB - Objective: Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuous distribution of inattentive and hyperactive behaviors. This hypothesis can be tested by assessing the predictive value of polygenic risk scores derived from a discovery sample of ADHD patients in a target sample from the general population with continuous scores of inattention and hyperactivity. In addition, the genetic overlap between ADHD and continuous ADHD scores can be tested across rater and age.
U2 - 10.1016/j.jaac.2014.06.014
DO - 10.1016/j.jaac.2014.06.014
M3 - Article
SN - 0890-8567
VL - 53
SP - 1123
EP - 1129
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 10
ER -