Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children

M.M. Blokhuis; C.M. Middeldorp; K.J. Kan; A. Abdellaoui; C.E.M. van Beijsterveldt; E.A. Ehli; G.E. Davies; P. Scheet; X. Xiao; J.J. Hudziak; J.J. Hottenga; B.M. Neale; D.I. Boomsma

doi:10.1016/j.jaac.2014.06.014

Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children

M.M. Blokhuis
, C.M. Middeldorp
, K.J. Kan
, A. Abdellaoui
, C.E.M. van Beijsterveldt
, E.A. Ehli
, G.E. Davies
, P. Scheet
, X. Xiao
, J.J. Hudziak
, J.J. Hottenga
, B.M. Neale
, D.I. Boomsma

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective: Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuous distribution of inattentive and hyperactive behaviors. This hypothesis can be tested by assessing the predictive value of polygenic risk scores derived from a discovery sample of ADHD patients in a target sample from the general population with continuous scores of inattention and hyperactivity. In addition, the genetic overlap between ADHD and continuous ADHD scores can be tested across rater and age.

Original language	English
Pages (from-to)	1123-1129
Number of pages	7
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	53
Issue number	10
DOIs	https://doi.org/10.1016/j.jaac.2014.06.014
Publication status	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 4 Quality Education

Cohort Studies

Netherlands Twin Register (NTR)

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10.1016/j.jaac.2014.06.014

http://www.tweelingenregister.org/publicaties

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Blokhuis, M. M., Middeldorp, C. M., Kan, K. J., Abdellaoui, A., van Beijsterveldt, C. E. M., Ehli, E. A., Davies, G. E., Scheet, P., Xiao, X., Hudziak, J. J., Hottenga, J. J., Neale, B. M., & Boomsma, D. I. (2014). Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children. Journal of the American Academy of Child and Adolescent Psychiatry, 53(10), 1123-1129. https://doi.org/10.1016/j.jaac.2014.06.014

@article{4b44e83443834254a7c3722c2c46226f,

title = "Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children",

abstract = "Objective: Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuous distribution of inattentive and hyperactive behaviors. This hypothesis can be tested by assessing the predictive value of polygenic risk scores derived from a discovery sample of ADHD patients in a target sample from the general population with continuous scores of inattention and hyperactivity. In addition, the genetic overlap between ADHD and continuous ADHD scores can be tested across rater and age.",

author = "M.M. Blokhuis and C.M. Middeldorp and K.J. Kan and A. Abdellaoui and \{van Beijsterveldt\}, C.E.M. and E.A. Ehli and G.E. Davies and P. Scheet and X. Xiao and J.J. Hudziak and J.J. Hottenga and B.M. Neale and D.I. Boomsma",

year = "2014",

doi = "10.1016/j.jaac.2014.06.014",

language = "English",

volume = "53",

pages = "1123--1129",

journal = "Journal of the American Academy of Child and Adolescent Psychiatry",

issn = "0890-8567",

publisher = "Elsevier Inc.",

number = "10",

}

Blokhuis, MM, Middeldorp, CM, Kan, KJ, Abdellaoui, A, van Beijsterveldt, CEM, Ehli, EA, Davies, GE, Scheet, P, Xiao, X, Hudziak, JJ, Hottenga, JJ, Neale, BM & Boomsma, DI 2014, 'Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 53, no. 10, pp. 1123-1129. https://doi.org/10.1016/j.jaac.2014.06.014

Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children. / Blokhuis, M.M.; Middeldorp, C.M.; Kan, K.J. et al.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 53, No. 10, 2014, p. 1123-1129.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children

AU - Blokhuis, M.M.

AU - Middeldorp, C.M.

AU - Kan, K.J.

AU - Abdellaoui, A.

AU - van Beijsterveldt, C.E.M.

AU - Ehli, E.A.

AU - Davies, G.E.

AU - Scheet, P.

AU - Xiao, X.

AU - Hudziak, J.J.

AU - Hottenga, J.J.

AU - Neale, B.M.

AU - Boomsma, D.I.

PY - 2014

Y1 - 2014

N2 - Objective: Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuous distribution of inattentive and hyperactive behaviors. This hypothesis can be tested by assessing the predictive value of polygenic risk scores derived from a discovery sample of ADHD patients in a target sample from the general population with continuous scores of inattention and hyperactivity. In addition, the genetic overlap between ADHD and continuous ADHD scores can be tested across rater and age.

AB - Objective: Clinically, attention-deficit/hyperactivity disorder (ADHD) is characterized by hyperactivity, impulsivity, and inattention and is among the most common childhood disorders. These same traits that define ADHD are variable in the general population, and the clinical diagnosis may represent the extreme end of a continuous distribution of inattentive and hyperactive behaviors. This hypothesis can be tested by assessing the predictive value of polygenic risk scores derived from a discovery sample of ADHD patients in a target sample from the general population with continuous scores of inattention and hyperactivity. In addition, the genetic overlap between ADHD and continuous ADHD scores can be tested across rater and age.

U2 - 10.1016/j.jaac.2014.06.014

DO - 10.1016/j.jaac.2014.06.014

M3 - Article

SN - 0890-8567

VL - 53

SP - 1123

EP - 1129

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 10

ER -

Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children

Abstract

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