Attenuation coefficient estimation in Fourier-domain OCT of multi-layered phantoms

BABAK GHAFARYASL*, KOENRAAD A. VERMEER, JEROEN KALKMAN, TOM CALLEWAERT, JOHANNES F. DE BOER, LUCAS J. VAN VLIET

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Optical properties, such as the attenuation coefficients of multi-layer tissue samples, could be used as a biomarker for diagnosis and disease progression in clinical practice. In this paper, we present a method to estimate the attenuation coefficients in a multi-layer sample by fitting a single scattering model for the OCT signal to the recorded OCT signal. In addition, we employ numerical simulations to obtain the theoretically achievable precision and accuracy of the estimated parameters under various experimental conditions. Finally, the method is applied to two sets of measurements obtained from a multi-layer phantom by two experimental OCT systems: One with a large and one with a small Rayleigh length. Numerical and experimental results show an accurate estimation of the attenuation coefficients when using multiple B-scans.

Original languageEnglish
Pages (from-to)2744-2758
Number of pages15
JournalBiomedical Optics Express
Volume12
Issue number5
Early online date15 Apr 2021
DOIs
Publication statusPublished - 1 May 2021

Bibliographical note

Funding Information:
Acknowledgment. This research was funded by the Netherlands Organization for Health Research and Development (ZonMw) TOP grant (91212061). We would like to acknowledge Jelmer Weda, BSc, (Department of Physics and Astronomy, Vrije Universiteit Amsterdam, The Netherlands) for his technical support in this work.

Publisher Copyright:
© 2021 Optical Society of America.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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