Atypical chemokine receptor 3 (ACKR3): A comprehensive overview of its expression and potential roles in the immune system

Joyce Koenen; Françoise Bachelerie; Karl Balabanian; Géraldine Schlecht-Louf; Carmen Gallego

doi:10.1124/mol.118.115329

Atypical chemokine receptor 3 (ACKR3): A comprehensive overview of its expression and potential roles in the immune system

Joyce Koenen^*, Françoise Bachelerie, Karl Balabanian, Géraldine Schlecht-Louf, Carmen Gallego

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Atypical chemokine receptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as a key player in several biologic processes, particularly during development. Its CXCL11 and CXCL12 scavenging activity and atypical signaling properties, together with a new array of other nonchemokine ligands, have established ACKR3 as a main regulator of physiologic processes at steady state and during inflammation. Here, we present a comprehensive review of ACKR3 expression in mammalian tissues in search of a possible connection with the receptor function. Besides the reported roles of ACKR3 during development, we discuss the potential contribution of ACKR3 to the function of the immune system, focusing on the myeloid lineage.

Original language	English
Pages (from-to)	809-818
Number of pages	10
Journal	Molecular pharmacology
Volume	96
Issue number	6
DOIs	https://doi.org/10.1124/mol.118.115329
Publication status	Published - Dec 2019

Funding

This mini-review is part of the mini-review series entitled “From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function.” This research was funded by the European Union’s Horizon 2020 MSCA Program [Grant agreement 641833 ONCORNET] to all authors, by European Union’s Infect-ERA project HPV-Motiva [ANR-15-IFEC-0004-0] to F.B. and G.S.-L., and by a PRC ANR Grant OSTEOVALYMPH [17-CE14-0019] coordinated by K.B. All authors are members of the LabEx LERMIT supported by ANR grant [ANR-10-LABX-33] under the program “Investissements d’Avenir” [ANR-11-IDEX-0003-01]. C.G. is beneficiary of a fellowship from Fondation de la Recherche Medicale (FRM).

Funders	Funder number
European Union?s Horizon 2020 MSCA
European Union’s Horizon 2020	ANR-15-IFEC-0004-0, 641833 ONCORNET
F.B.
Fondation de la Recherche Medicale	FRM
PRC ANR	17-CE14-0019
Horizon 2020 Framework Programme	641833
LabEx ASLAN	ANR-10-LABX-33, ANR-11-IDEX-0003-01
Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Atypical chemokine receptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as a key player in several biologic processes, particularly during development. Its CXCL11 and CXCL12 scavenging activity and atypical signaling properties, together with a new array of other nonchemokine ligands, have established ACKR3 as a main regulator of physiologic processes at steady state and during inflammation. Here, we present a comprehensive review of ACKR3 expression in mammalian tissues in search of a possible connection with the receptor function. Besides the reported roles of ACKR3 during development, we discuss the potential contribution of ACKR3 to the function of the immune system, focusing on the myeloid lineage.",

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Atypical chemokine receptor 3 (ACKR3): A comprehensive overview of its expression and potential roles in the immune system

Abstract

Funding

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