AMPA receptors mediate fast synaptic transmission in the CNS and can assemble with several types of auxiliary proteins in a spatio-temporal manner, from newly synthesized AMPA receptor tetramers to mature AMPA receptors in the cell membrane. As such, the interaction of auxiliary subunits with the AMPA receptor plays a major role in the regulation of AMPA receptor biogenesis, trafficking, and biophysical properties. Throughout the years, various ‘families’ of proteins have been identified and today the approximate full complement of AMPAR auxiliary proteins is known. This review presents the current knowledge on the most prominent AMPA-receptor-interacting auxiliary proteins, highlights recent results regarding the Shisa protein family, and provides a discussion on future research that might contribute to the discovery of novel pharmacological targets of auxiliary subunits.

Original languageEnglish
Pages (from-to)52-61
Number of pages10
JournalCurrent Opinion in Pharmacology
Early online date21 Apr 2021
Publication statusPublished - Jun 2021

Bibliographical note

Publisher Copyright:
© 2021

Copyright 2021 Elsevier B.V., All rights reserved.


  • Auxiliary proteins
  • Ionotropic glutamate receptor
  • Modulation of channel function
  • Receptor targeting


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