Axonal and presynaptic protein synthesis: new insights into the biology of the neuron

A. Giuditta, B.B. Kaplan, J. van Minnen, J. Alvarez, E. Koenig

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The presence of a local mRNA translation system in axons and terminals was proposed almost 40 years ago. Over the ensuing period, an impressive body of evidence has grown to support this proposal - yet the nerve cell body is still considered to be the only source of axonal and presynaptic proteins. To dispel this lingering neglect, we now present the wealth of recent observations bearing on this central idea, and consider their impact on our understanding of the biology of the neuron. We demonstrate that extrasomatic translation sites, which are now well recognized in dendrites, are also present in axonal and presynaptic compartments.
Original languageEnglish
Pages (from-to)400-404
Number of pages5
JournalTrends in Neurosciences
Volume25
Issue number8
DOIs
Publication statusPublished - 2002

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