Abstract
© 2020 Wiley-VCH GmbHNon-covalent interactions are important for directing protein folding across multiple intermediates and can even provide access to multiple stable structures with different properties and functions. Herein, we describe an approach for mimicking this behavior in the self-assembly of metal–organic cages. Two ligands, the bend angles of which are controlled by non-covalent interactions and one ligand lacking the above-mentioned interactions, were synthesized and used for self-assembly with Pd2+. As these weak interactions are easily broken, the bend angles have a controlled flexibility giving access to M2(L1)4, M6(L2)12, and M12(L2)24 cages. By controlling the self-assembly conditions this process can be directed in a stepwise fashion. Additionally, the multiple endohedral hydrogen-bonding sites on the ligand were found to play a role in the binding and discrimination of neutral guests.
Original language | English |
---|---|
Pages (from-to) | 11960-11965 |
Journal | Chemistry - A European Journal |
Volume | 26 |
Issue number | 52 |
DOIs | |
Publication status | Published - 16 Sept 2020 |
Externally published | Yes |
Funding
This work was supported in part through the Concerted Research Action (ARC16/21‐074). C.‐L.L. and Y.F were supported by fellowships from the China Scholarship Council. Computational resources have been provided by the supercomputing facilities of the Université catholique de Louvain (CISM/UCL) and the Consortium des équipements de Calcul Intensif en Fédération Wallonie Bruxelles (CPCI) funded by the Fond de la Recherche Scientifique de Belgique (F.R.S.‐FNRS) under convention 2.5020.11. We also thank Dr. G. Barozzino for help with NMR measurements.
Funders | Funder number |
---|---|
CISM | |
CPCI | |
Concerted Research Action | ARC16/21‐074 |
Consortium des équipements de Calcul Intensif en Fédération Wallonie Bruxelles | |
F.R.S.‐FNRS | |
Fond de la Recherche Scientifique de Belgique | |
Université Catholique de Louvain | |
China Scholarship Council | |
Université Catholique de Louvain |