TY - JOUR
T1 - Behavioral and molecular genetics of dissociation
T2 - The role of the serotonin transporter gene promoter polymorphism (5-HTTLPR)
AU - Pieper, Suzanne
AU - Out, Dorothée
AU - Bakermans-Kranenburg, Marian J.
AU - van Ijzendoorn, Marinus H.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - We evaluated the role of the serotonin transporter gene promoter polymorphism (5-HTTLPR) in the etiology of dissociation. Adult twin pairs (N = 184 pairs; mean age 33.0 years, SD = 10.8) completed measures for dissociation and trauma. The DNA samples were genotyped for 5-HTTLPR adjusted for rs25531 alleles. Behavioral genetic analyses showed that genetic factors explained 45% of the variance in dissociative symptoms, while 55% of the variance was explained by unique environment and measurement error. Participants with the SS genotype of 5-HTTLPR reported more dissociative symptoms compared to participants with the other genotypes (p = .02), and they showed more pathological dissociative symptoms than the other participants (p = .04) when they reported more depressive symptoms and when they had experienced trauma.
AB - We evaluated the role of the serotonin transporter gene promoter polymorphism (5-HTTLPR) in the etiology of dissociation. Adult twin pairs (N = 184 pairs; mean age 33.0 years, SD = 10.8) completed measures for dissociation and trauma. The DNA samples were genotyped for 5-HTTLPR adjusted for rs25531 alleles. Behavioral genetic analyses showed that genetic factors explained 45% of the variance in dissociative symptoms, while 55% of the variance was explained by unique environment and measurement error. Participants with the SS genotype of 5-HTTLPR reported more dissociative symptoms compared to participants with the other genotypes (p = .02), and they showed more pathological dissociative symptoms than the other participants (p = .04) when they reported more depressive symptoms and when they had experienced trauma.
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U2 - 10.1002/jts.20659
DO - 10.1002/jts.20659
M3 - Article
C2 - 21780190
AN - SCOPUS:80051869606
VL - 24
SP - 373
EP - 380
JO - Journal of Traumatic Stress
JF - Journal of Traumatic Stress
SN - 0894-9867
IS - 4
ER -