Behavioral and molecular genetics of dissociation: The role of the serotonin transporter gene promoter polymorphism (5-HTTLPR)

Suzanne Pieper; Dorothée Out; Marian J. Bakermans-Kranenburg; Marinus H. van Ijzendoorn

doi:10.1002/jts.20659

Behavioral and molecular genetics of dissociation: The role of the serotonin transporter gene promoter polymorphism (5-HTTLPR)

Suzanne Pieper, Dorothée Out, Marian J. Bakermans-Kranenburg^*, Marinus H. van Ijzendoorn

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

We evaluated the role of the serotonin transporter gene promoter polymorphism (5-HTTLPR) in the etiology of dissociation. Adult twin pairs (N = 184 pairs; mean age 33.0 years, SD = 10.8) completed measures for dissociation and trauma. The DNA samples were genotyped for 5-HTTLPR adjusted for rs25531 alleles. Behavioral genetic analyses showed that genetic factors explained 45% of the variance in dissociative symptoms, while 55% of the variance was explained by unique environment and measurement error. Participants with the SS genotype of 5-HTTLPR reported more dissociative symptoms compared to participants with the other genotypes (p = .02), and they showed more pathological dissociative symptoms than the other participants (p = .04) when they reported more depressive symptoms and when they had experienced trauma.

Original language	English
Pages (from-to)	373-380
Number of pages	8
Journal	Journal of Traumatic Stress
Volume	24
Issue number	4
DOIs	https://doi.org/10.1002/jts.20659
Publication status	Published - 1 Aug 2011
Externally published	Yes

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title = "Behavioral and molecular genetics of dissociation: The role of the serotonin transporter gene promoter polymorphism (5-HTTLPR)",

abstract = "We evaluated the role of the serotonin transporter gene promoter polymorphism (5-HTTLPR) in the etiology of dissociation. Adult twin pairs (N = 184 pairs; mean age 33.0 years, SD = 10.8) completed measures for dissociation and trauma. The DNA samples were genotyped for 5-HTTLPR adjusted for rs25531 alleles. Behavioral genetic analyses showed that genetic factors explained 45% of the variance in dissociative symptoms, while 55% of the variance was explained by unique environment and measurement error. Participants with the SS genotype of 5-HTTLPR reported more dissociative symptoms compared to participants with the other genotypes (p = .02), and they showed more pathological dissociative symptoms than the other participants (p = .04) when they reported more depressive symptoms and when they had experienced trauma.",

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Behavioral and molecular genetics of dissociation : The role of the serotonin transporter gene promoter polymorphism (5-HTTLPR). / Pieper, Suzanne; Out, Dorothée; Bakermans-Kranenburg, Marian J.; van Ijzendoorn, Marinus H.

In: Journal of Traumatic Stress, Vol. 24, No. 4, 01.08.2011, p. 373-380.

Research output: Contribution to Journal › Article › Academic › peer-review

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