Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice

M.L. Chanda, A.H. Tuttle, I. Baran, C. Atlin, D. Guindi, G. Hathaway, N. Israelian, J. Levenstadt, D. Low, L. Macrae, L. O'Shea, A. Silver, E. Zendegui, A.M. Lenselink, S. Spijker, M.D. Ferrari, J.S. Mogil

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence of hallmark migraine features, photophobia and unilateral head pain, in transgenic knock-in mice bearing human familial hemiplegic migraine, type 1 (FHM-1) gain-of-function missense mutations (R192Q or S218L) in the Cacna1a gene encoding the Ca
Original languageEnglish
Pages (from-to)1254-1262
JournalPain
Volume154
Issue number8
DOIs
Publication statusPublished - 2013

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    Chanda, M. L., Tuttle, A. H., Baran, I., Atlin, C., Guindi, D., Hathaway, G., Israelian, N., Levenstadt, J., Low, D., Macrae, L., O'Shea, L., Silver, A., Zendegui, E., Lenselink, A. M., Spijker, S., Ferrari, M. D., & Mogil, J. S. (2013). Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice. Pain, 154(8), 1254-1262. https://doi.org/10.1016/j.pain.2013.03.038