Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice

M.L. Chanda; A.H. Tuttle; I. Baran; C. Atlin; D. Guindi; G. Hathaway; N. Israelian; J. Levenstadt; D. Low; L. Macrae; L. O'Shea; A. Silver; E. Zendegui; A.M. Lenselink; S. Spijker; M.D. Ferrari; J.S. Mogil

doi:10.1016/j.pain.2013.03.038

Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice

M.L. Chanda, A.H. Tuttle, I. Baran, C. Atlin, D. Guindi, G. Hathaway, N. Israelian, J. Levenstadt, D. Low, L. Macrae, L. O'Shea, A. Silver, E. Zendegui, A.M. Lenselink, S. Spijker, M.D. Ferrari, J.S. Mogil

Molecular and Cellular Neurobiology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence of hallmark migraine features, photophobia and unilateral head pain, in transgenic knock-in mice bearing human familial hemiplegic migraine, type 1 (FHM-1) gain-of-function missense mutations (R192Q or S218L) in the Cacna1a gene encoding the Ca

Original language	English
Pages (from-to)	1254-1262
Journal	Pain
Volume	154
Issue number	8
DOIs	https://doi.org/10.1016/j.pain.2013.03.038
Publication status	Published - 2013

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Chanda, M. L., Tuttle, A. H., Baran, I., Atlin, C., Guindi, D., Hathaway, G., Israelian, N., Levenstadt, J., Low, D., Macrae, L., O'Shea, L., Silver, A., Zendegui, E., Lenselink, A. M., Spijker, S., Ferrari, M. D., & Mogil, J. S. (2013). Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice. Pain, 154(8), 1254-1262. https://doi.org/10.1016/j.pain.2013.03.038

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title = "Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice",

abstract = "Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence of hallmark migraine features, photophobia and unilateral head pain, in transgenic knock-in mice bearing human familial hemiplegic migraine, type 1 (FHM-1) gain-of-function missense mutations (R192Q or S218L) in the Cacna1a gene encoding the Ca",

author = "M.L. Chanda and A.H. Tuttle and I. Baran and C. Atlin and D. Guindi and G. Hathaway and N. Israelian and J. Levenstadt and D. Low and L. Macrae and L. O'Shea and A. Silver and E. Zendegui and A.M. Lenselink and S. Spijker and M.D. Ferrari and J.S. Mogil",

year = "2013",

doi = "10.1016/j.pain.2013.03.038",

language = "English",

volume = "154",

pages = "1254--1262",

journal = "Pain",

issn = "0304-3959",

publisher = "Lippincott Williams & Wilkins",

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}

Chanda, ML, Tuttle, AH, Baran, I, Atlin, C, Guindi, D, Hathaway, G, Israelian, N, Levenstadt, J, Low, D, Macrae, L, O'Shea, L, Silver, A, Zendegui, E, Lenselink, AM, Spijker, S, Ferrari, MD & Mogil, JS 2013, 'Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice', Pain, vol. 154, no. 8, pp. 1254-1262. https://doi.org/10.1016/j.pain.2013.03.038

TY - JOUR

T1 - Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice

AU - Chanda, M.L.

AU - Tuttle, A.H.

AU - Baran, I.

AU - Atlin, C.

AU - Guindi, D.

AU - Hathaway, G.

AU - Israelian, N.

AU - Levenstadt, J.

AU - Low, D.

AU - Macrae, L.

AU - O'Shea, L.

AU - Silver, A.

AU - Zendegui, E.

AU - Lenselink, A.M.

AU - Spijker, S.

AU - Ferrari, M.D.

AU - Mogil, J.S.

PY - 2013

Y1 - 2013

N2 - Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence of hallmark migraine features, photophobia and unilateral head pain, in transgenic knock-in mice bearing human familial hemiplegic migraine, type 1 (FHM-1) gain-of-function missense mutations (R192Q or S218L) in the Cacna1a gene encoding the Ca

AB - Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence of hallmark migraine features, photophobia and unilateral head pain, in transgenic knock-in mice bearing human familial hemiplegic migraine, type 1 (FHM-1) gain-of-function missense mutations (R192Q or S218L) in the Cacna1a gene encoding the Ca

U2 - 10.1016/j.pain.2013.03.038

DO - 10.1016/j.pain.2013.03.038

M3 - Article

SN - 0304-3959

VL - 154

SP - 1254

EP - 1262

JO - Pain

JF - Pain

IS - 8

ER -

Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice

Abstract

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