Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates.

J.N.M. Commandeur; L.J. King; L. Koymans; N.P.E. Vermeulen

doi:10.1021/tx960049b

Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates.

J.N.M. Commandeur, L.J. King, L. Koymans, N.P.E. Vermeulen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The covalent binding of reactive intermediates, formed by β-elimination of cysteine S-conjugates of halogenated alkenes, to nucleophiles was studied using

Original language	English
Pages (from-to)	1092-1102
Journal	Chemical Research in Toxicology
Volume	9
DOIs	https://doi.org/10.1021/tx960049b
Publication status	Published - 1996

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Commandeur, J. N. M., King, L. J., Koymans, L., & Vermeulen, N. P. E. (1996). Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates. Chemical Research in Toxicology, 9, 1092-1102. https://doi.org/10.1021/tx960049b

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title = "Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates.",

abstract = "The covalent binding of reactive intermediates, formed by β-elimination of cysteine S-conjugates of halogenated alkenes, to nucleophiles was studied using",

author = "J.N.M. Commandeur and L.J. King and L. Koymans and N.P.E. Vermeulen",

year = "1996",

doi = "10.1021/tx960049b",

language = "English",

volume = "9",

pages = "1092--1102",

journal = "Chemical Research in Toxicology",

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publisher = "American Chemical Society",

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Commandeur, JNM, King, LJ, Koymans, L & Vermeulen, NPE 1996, 'Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates.', Chemical Research in Toxicology, vol. 9, pp. 1092-1102. https://doi.org/10.1021/tx960049b

Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates. / Commandeur, J.N.M.; King, L.J.; Koymans, L. et al.
In: Chemical Research in Toxicology, Vol. 9, 1996, p. 1092-1102.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates.

AU - Commandeur, J.N.M.

AU - King, L.J.

AU - Koymans, L.

AU - Vermeulen, N.P.E.

PY - 1996

Y1 - 1996

N2 - The covalent binding of reactive intermediates, formed by β-elimination of cysteine S-conjugates of halogenated alkenes, to nucleophiles was studied using

AB - The covalent binding of reactive intermediates, formed by β-elimination of cysteine S-conjugates of halogenated alkenes, to nucleophiles was studied using

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DO - 10.1021/tx960049b

M3 - Article

SN - 0893-228X

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JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

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Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates.

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