Biochemical changes in irradiated oral mucosa: A FTIR spectroscopic study

H. Ukkonen, S. Vuokila, J.J.W. Mikkonen, H. Dekker, E.A.J.M. Schulten, E. Bloemena, A. Koistinen, T.A. Valdez, A.M. Kullaa, S.P. Singh

Research output: Contribution to JournalArticleAcademicpeer-review


Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical maps generated using glycoprotein band indicates its differential distribution along the superficial layer. Spectra extracted from this layer suggests changes in overall nucleic acid and protein content in response to the therapeutic irradiation. Discrimination among control and irradiated groups have been achieved using principal component analysis. Findings of this preliminary study further support prospective utilization of Fourier Transform InfraRed (FTIR) imaging as a non-destructive, label-free tool for objective assessment of the oral mucosa in patient groups with or without radiation therapy.

Original languageEnglish
Article number12
Number of pages8
Issue number1
Publication statusPublished - 1 Mar 2019


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