Biofunctionalized lipid-polymer hybrid nanocontainers with controlled permeability

Alma Dudia; Armagan Koçer; Vinod Subramaniam; Johannes S Kanger

doi:10.1021/nl073211b

Biofunctionalized lipid-polymer hybrid nanocontainers with controlled permeability

Alma Dudia, Armagan Koçer, Vinod Subramaniam, Johannes S Kanger

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

We have successfully developed, for the first time, a novel polymer-lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.

Original language	English
Pages (from-to)	1105-10
Number of pages	6
Journal	Nano Letters
Volume	8
Issue number	4
DOIs	https://doi.org/10.1021/nl073211b
Publication status	Published - Apr 2008

Keywords

Lipids
Nanostructures
Permeability
Polymers
Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1021/nl073211b

Handle.net

Persistent link

Cite this

@article{10ed198257ba4b5c86b6f1faaa96e912,

title = "Biofunctionalized lipid-polymer hybrid nanocontainers with controlled permeability",

abstract = "We have successfully developed, for the first time, a novel polymer-lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.",

keywords = "Lipids, Nanostructures, Permeability, Polymers, Journal Article, Research Support, Non-U.S. Gov't",

author = "Alma Dudia and Armagan Ko{\c c}er and Vinod Subramaniam and Kanger, {Johannes S}",

year = "2008",

month = apr,

doi = "10.1021/nl073211b",

language = "English",

volume = "8",

pages = "1105--10",

journal = "Nano Letters",

issn = "1530-6984",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Biofunctionalized lipid-polymer hybrid nanocontainers with controlled permeability

AU - Dudia, Alma

AU - Koçer, Armagan

AU - Subramaniam, Vinod

AU - Kanger, Johannes S

PY - 2008/4

Y1 - 2008/4

N2 - We have successfully developed, for the first time, a novel polymer-lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.

AB - We have successfully developed, for the first time, a novel polymer-lipid hybrid nanocontainer with controlled permeability functionality. The nanocontainer is made by nanofabricating holes with desired dimensions in an impermeable polymer scaffold by focused ion beam drilling and sealing them with lipid bilayers containing remote-controlled pore-forming channel proteins. This system allows exchange of solutions only after channel activation at will to form temporary pores in the container. Potential applications are foreseen in bionanosensors, nanoreactors, nanomedicine, and triggered delivery.

KW - Lipids

KW - Nanostructures

KW - Permeability

KW - Polymers

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1021/nl073211b

DO - 10.1021/nl073211b

M3 - Article

C2 - 18311934

SN - 1530-6984

VL - 8

SP - 1105

EP - 1110

JO - Nano Letters

JF - Nano Letters

IS - 4

ER -

Biofunctionalized lipid-polymer hybrid nanocontainers with controlled permeability

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this