Biogenesis of inner membrane proteins in Escherichia coli.

S. Luirink, Z. Yu, S. Wagner, J.W. de Gier

Research output: Contribution to JournalArticleAcademic


The inner membrane proteome of the model organism Escherichia coli is composed of inner membrane proteins, lipoproteins and peripherally attached soluble proteins. Our knowledge of the biogenesis of inner membrane proteins is rapidly increasing. This is in particular true for the early steps of biogenesis - protein targeting to and insertion into the membrane. However, our knowledge of inner membrane protein folding and quality control is still fragmentary. Furthering our knowledge in these areas will bring us closer to understand the biogenesis of individual inner membrane proteins in the context of the biogenesis of the inner membrane proteome of Escherichia coli as a whole. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. © 2011 Elsevier B.V.
Original languageEnglish
Pages (from-to)965-976
JournalBiochimica et Biophysica Acta (BBA) - Bioenergetics
Issue number6
Early online date19 Dec 2011
Publication statusPublished - 2012


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