Biomimetic Models of the Actin Cytoskeleton

C. Mohrdieck; F. Dalmas; E. Arzt; R. Tharmann; M.M.A.E. Claessens; A.R. Bausch; C. Schmitz; J. Curtis; W.H. Roos; S. Schultz; K. Uhrig; A. Roth; E. Sackmann; J.P. Spatz

doi:10.1002/smll.200600565

Biomimetic Models of the Actin Cytoskeleton

C. Mohrdieck, F. Dalmas, E. Arzt, R. Tharmann, M.M.A.E. Claessens, A.R. Bausch, C. Schmitz, J. Curtis, W.H. Roos, S. Schultz, K. Uhrig, A. Roth, E. Sackmann, J.P. Spatz

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The cytoskeleton is a complex polymer network that plays an essential role in the functionality of eukaryotic cells. It endows cells with mechanical stability, adaptability, and motility. To identify and understand the mechanisms underlying this large variety of capabilities and to possibly transfer them to engineered networks makes it necessary to have in vitro and in silico model systems of the cytoskeleton. These models must be realistic representatives of the cellular network and at the same time be controllable and reproducible. Here, an approach to design complementary experimental and numerical model systems of the actin cytoskeleton is presented and some of their properties discussed. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	1015-1022
Journal	Small
Volume	3
Issue number	6
DOIs	https://doi.org/10.1002/smll.200600565
Publication status	Published - 2007

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title = "Biomimetic Models of the Actin Cytoskeleton",

abstract = "The cytoskeleton is a complex polymer network that plays an essential role in the functionality of eukaryotic cells. It endows cells with mechanical stability, adaptability, and motility. To identify and understand the mechanisms underlying this large variety of capabilities and to possibly transfer them to engineered networks makes it necessary to have in vitro and in silico model systems of the cytoskeleton. These models must be realistic representatives of the cellular network and at the same time be controllable and reproducible. Here, an approach to design complementary experimental and numerical model systems of the actin cytoskeleton is presented and some of their properties discussed. {\textcopyright} 2007 Wiley-VCH Verlag GmbH & Co. KGaA.",

author = "C. Mohrdieck and F. Dalmas and E. Arzt and R. Tharmann and M.M.A.E. Claessens and A.R. Bausch and C. Schmitz and J. Curtis and W.H. Roos and S. Schultz and K. Uhrig and A. Roth and E. Sackmann and J.P. Spatz",

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T1 - Biomimetic Models of the Actin Cytoskeleton

AU - Mohrdieck, C.

AU - Dalmas, F.

AU - Arzt, E.

AU - Tharmann, R.

AU - Claessens, M.M.A.E.

AU - Bausch, A.R.

AU - Schmitz, C.

AU - Curtis, J.

AU - Roos, W.H.

AU - Schultz, S.

AU - Uhrig, K.

AU - Roth, A.

AU - Sackmann, E.

AU - Spatz, J.P.

PY - 2007

Y1 - 2007

N2 - The cytoskeleton is a complex polymer network that plays an essential role in the functionality of eukaryotic cells. It endows cells with mechanical stability, adaptability, and motility. To identify and understand the mechanisms underlying this large variety of capabilities and to possibly transfer them to engineered networks makes it necessary to have in vitro and in silico model systems of the cytoskeleton. These models must be realistic representatives of the cellular network and at the same time be controllable and reproducible. Here, an approach to design complementary experimental and numerical model systems of the actin cytoskeleton is presented and some of their properties discussed. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - The cytoskeleton is a complex polymer network that plays an essential role in the functionality of eukaryotic cells. It endows cells with mechanical stability, adaptability, and motility. To identify and understand the mechanisms underlying this large variety of capabilities and to possibly transfer them to engineered networks makes it necessary to have in vitro and in silico model systems of the cytoskeleton. These models must be realistic representatives of the cellular network and at the same time be controllable and reproducible. Here, an approach to design complementary experimental and numerical model systems of the actin cytoskeleton is presented and some of their properties discussed. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

U2 - 10.1002/smll.200600565

DO - 10.1002/smll.200600565

M3 - Article

SN - 1613-6810

VL - 3

SP - 1015

EP - 1022

JO - Small

JF - Small

IS - 6

ER -

Biomimetic Models of the Actin Cytoskeleton

Abstract

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