Abstract
A single biomineralization of demineralized dentin is significant to restore the demineralized dentin due to dental caries or erosion. In recent years, meaningful progress has been made regarding the mechanisms involved in the biomineralization of dentin collagen. Concepts changing from the classical ion-based crystallization to non-classical particle-based crystallization, inspired a different strategy to infiltrate the demineralized dentin collagen. The remarkable discovery was the report of liquid-like amorphous calcium phosphate as nanoprecursor particles to carbonated hydroxyapatite. The non-collagenous proteins and their analogues are widely investigated, for their key role in controlling mineralization during the process of crystal nucleation and growth. The in-depth studies of the gap zone provided significant improvements in our understanding of the structure of collagen and of the intrafibrillar remineralization of collagen fibrils. The collagen is not a passive substrate as previously supposed, and the active role of guiding nanoprecursor infiltration and mediating its nucleation has been demonstrated. Furthermore, recovery of mechanical properties has been evaluated to determine the effectiveness of dentin remineralization. Finally, the problems regarding the origin formation of the calcium phosphate that is deposited in the collagen, and the exact interactions between the non-collagenous proteins, amorphous calcium phosphate and collagen are still unclear. We reviewed the importance of these findings in enriching our understanding of dentin biomineralization, while addressing certain limitations that are inherent to in vitro studies.
Original language | English |
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Pages (from-to) | 115-122 |
Journal | Journal of Structural Biology |
Volume | 207 |
Issue number | 2 |
DOIs | |
Publication status | Published - Aug 2019 |
Bibliographical note
Export Date: 22 October 2019CODEN: JSBIE
Funding
The authors thank all scientists that have authored the papers presented in this review. This review article was supported by The National Natural Science Foundation of China ( 81870759 ) and Chengdu Technological Innovation and R&D project 2018-YF05-00249-SN(LC), Innovative Research Team Program of Sichuan Province (LC).
Funders | Funder number |
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Chengdu Technological Innovation | 2018-YF05-00249-SN |
Innovative Research Team Program of Sichuan Province | |
National Natural Science Foundation of China | 81870759 |