Biophysical modeling of a Drosophila photoreceptor

Zhuoyi Song*, Daniel Coca, Stephen Billings, Marten Postma, Roger C. Hardie, Mikko Juusola

*Corresponding author for this work

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Abstract

It remains unclear how visual information is co-processed by different layers of neurons in the retina. In particular, relatively little is known how retina translates vast environmental light changes into neural responses of limited range. We began examining this question in a bottom-up way in a relatively simple fly eye. To gain understanding of how complex bio-molecular interactions govern the conversion of light input into voltage output (phototransduction), we are building a biophysical model of the Drosophila R1-R6 photoreceptor. Our model, which relates molecular dynamics of the underlying biochemical reactions to external light input, attempts to capture the molecular dynamics of phototransduction gain control in a quantitative way.

Original languageEnglish
Title of host publicationNeural Information Processing - 16th International Conference, ICONIP 2009, Proceedings
Pages57-71
Number of pages15
EditionPART 1
DOIs
Publication statusPublished - 1 Dec 2009
Externally publishedYes
Event16th International Conference on Neural Information Processing, ICONIP 2009 - Bangkok, Thailand
Duration: 1 Dec 20095 Dec 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume5863 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference16th International Conference on Neural Information Processing, ICONIP 2009
CountryThailand
CityBangkok
Period1/12/095/12/09

Keywords

  • Biophysical model
  • Drosophila photoreceptor
  • Gillespie algorithm
  • Hodgkin-Huxley model
  • Phototransduction cascade

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