Biphasic Cell-Size and Growth-Rate Homeostasis by Single Bacillus subtilis Cells

Niclas Nordholt; Johan H. van Heerden; Frank J. Bruggeman

doi:10.1016/j.cub.2020.04.030

Biphasic Cell-Size and Growth-Rate Homeostasis by Single Bacillus subtilis Cells

Niclas Nordholt, Johan H. van Heerden, Frank J. Bruggeman^*

^*Corresponding author for this work

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Nordholt et al. show how growth-rate and protein-concentration homeostasis is achieved in Bacillus subtilis, through systematic rate adjustments during cell-cycle progression. They identify two distinct growth regimes in this bacterium's cell cycle, suggesting a link between growth-rate dynamics and size homeostasis.

Original language	English
Pages (from-to)	2238-2247.e5
Number of pages	16
Journal	Current Biology
Volume	30
Issue number	12
Early online date	14 May 2020
DOIs	https://doi.org/10.1016/j.cub.2020.04.030
Publication status	Published - 22 Jun 2020

Funding

F.J.B. acknowledges funding from NWO-VIDI project 864.11.011 . N.N. and F.J.B. received funding from the European Union , Marie Curie ITN AMBER, 317338 . J.H.v.H. and F.J.B. received funding from the EraSysApp grant RobustYeast. We wish to thank Erik van Nimwegen, Thomas Julou, and Pieter Rein ten Wolde for their feedback and suggestions.

Keywords

Bacillus subtilis
bacterial cell cycle
biphasic growth
growth-rate homeostasis
single cell microbiology
size homeostasis

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Biphasic Cell-Size and Growth-Rate Homeostasis by Single Bacillus subtilis Cells

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