Biphasic Cell-Size and Growth-Rate Homeostasis by Single Bacillus subtilis Cells

Niclas Nordholt; Johan H. van Heerden; Frank J. Bruggeman

doi:10.1016/j.cub.2020.04.030

Biphasic Cell-Size and Growth-Rate Homeostasis by Single Bacillus subtilis Cells

Niclas Nordholt, Johan H. van Heerden, Frank J. Bruggeman^*

^*Corresponding author for this work

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Nordholt et al. show how growth-rate and protein-concentration homeostasis is achieved in Bacillus subtilis, through systematic rate adjustments during cell-cycle progression. They identify two distinct growth regimes in this bacterium's cell cycle, suggesting a link between growth-rate dynamics and size homeostasis.

Original language	English
Pages (from-to)	2238-2247.e5
Number of pages	16
Journal	Current Biology
Volume	30
Issue number	12
Early online date	14 May 2020
DOIs	https://doi.org/10.1016/j.cub.2020.04.030
Publication status	Published - 22 Jun 2020

Keywords

Bacillus subtilis
bacterial cell cycle
biphasic growth
growth-rate homeostasis
single cell microbiology
size homeostasis

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title = "Biphasic Cell-Size and Growth-Rate Homeostasis by Single Bacillus subtilis Cells",

abstract = "Nordholt et al. show how growth-rate and protein-concentration homeostasis is achieved in Bacillus subtilis, through systematic rate adjustments during cell-cycle progression. They identify two distinct growth regimes in this bacterium's cell cycle, suggesting a link between growth-rate dynamics and size homeostasis.",

keywords = "Bacillus subtilis, bacterial cell cycle, biphasic growth, growth-rate homeostasis, single cell microbiology, size homeostasis",

author = "Niclas Nordholt and {van Heerden}, {Johan H.} and Bruggeman, {Frank J.}",

year = "2020",

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AU - van Heerden, Johan H.

AU - Bruggeman, Frank J.

PY - 2020/6/22

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AB - Nordholt et al. show how growth-rate and protein-concentration homeostasis is achieved in Bacillus subtilis, through systematic rate adjustments during cell-cycle progression. They identify two distinct growth regimes in this bacterium's cell cycle, suggesting a link between growth-rate dynamics and size homeostasis.

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KW - bacterial cell cycle

KW - biphasic growth

KW - growth-rate homeostasis

KW - single cell microbiology

KW - size homeostasis

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JO - Current Biology

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Biphasic Cell-Size and Growth-Rate Homeostasis by Single Bacillus subtilis Cells

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Keywords

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