Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

H. Engelhardt; S. Schultes; C. de Graaf; S. Nijmeijer; H.F. Vischer; O.B. Zuiderveld; J. Dobler; K. Stachurski; M. Mayer; H. Arnhof; D. Scharn; E.J.J. Haaksma; I.J.P. de Esch; R. Leurs

doi:10.1021/jm301886t

Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

H. Engelhardt, S. Schultes, C. de Graaf, S. Nijmeijer, H.F. Vischer, O.B. Zuiderveld, J. Dobler, K. Stachurski, M. Mayer, H. Arnhof, D. Scharn, E.J.J. Haaksma, I.J.P. de Esch, R. Leurs

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The basic methylpiperazine moiety is considered a necessary substructure for high histamine H

Original language	English
Pages (from-to)	4264-4276
Journal	Journal of Medicinal Chemistry
Volume	2013
Issue number	56
DOIs	https://doi.org/10.1021/jm301886t
Publication status	Published - 2013

Access to Document

10.1021/jm301886t

Cite this

Engelhardt, H., Schultes, S., de Graaf, C., Nijmeijer, S., Vischer, H. F., Zuiderveld, O. B., Dobler, J., Stachurski, K., Mayer, M., Arnhof, H., Scharn, D., Haaksma, E. J. J., de Esch, I. J. P., & Leurs, R. (2013). Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode. Journal of Medicinal Chemistry, 2013(56), 4264-4276. https://doi.org/10.1021/jm301886t

Engelhardt, H. ; Schultes, S. ; de Graaf, C. ; Nijmeijer, S. ; Vischer, H.F. ; Zuiderveld, O.B. ; Dobler, J. ; Stachurski, K. ; Mayer, M. ; Arnhof, H. ; Scharn, D. ; Haaksma, E.J.J. ; de Esch, I.J.P. ; Leurs, R. / Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode. In: Journal of Medicinal Chemistry. 2013 ; Vol. 2013, No. 56. pp. 4264-4276.

@article{80eb47cd1f934120a8cce5c4ab61b289,

title = "Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode",

abstract = "The basic methylpiperazine moiety is considered a necessary substructure for high histamine H",

author = "H. Engelhardt and S. Schultes and {de Graaf}, C. and S. Nijmeijer and H.F. Vischer and O.B. Zuiderveld and J. Dobler and K. Stachurski and M. Mayer and H. Arnhof and D. Scharn and E.J.J. Haaksma and {de Esch}, I.J.P. and R. Leurs",

year = "2013",

doi = "10.1021/jm301886t",

language = "English",

volume = "2013",

pages = "4264--4276",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "56",

}

Engelhardt, H, Schultes, S, de Graaf, C, Nijmeijer, S, Vischer, HF, Zuiderveld, OB, Dobler, J, Stachurski, K, Mayer, M, Arnhof, H, Scharn, D, Haaksma, EJJ , de Esch, IJP & Leurs, R 2013, 'Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode', Journal of Medicinal Chemistry, vol. 2013, no. 56, pp. 4264-4276. https://doi.org/10.1021/jm301886t

Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode. / Engelhardt, H.; Schultes, S.; de Graaf, C.; Nijmeijer, S.; Vischer, H.F.; Zuiderveld, O.B.; Dobler, J.; Stachurski, K.; Mayer, M.; Arnhof, H.; Scharn, D.; Haaksma, E.J.J.; de Esch, I.J.P.; Leurs, R.

In: Journal of Medicinal Chemistry, Vol. 2013, No. 56, 2013, p. 4264-4276.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

AU - Engelhardt, H.

AU - Schultes, S.

AU - de Graaf, C.

AU - Nijmeijer, S.

AU - Vischer, H.F.

AU - Zuiderveld, O.B.

AU - Dobler, J.

AU - Stachurski, K.

AU - Mayer, M.

AU - Arnhof, H.

AU - Scharn, D.

AU - Haaksma, E.J.J.

AU - de Esch, I.J.P.

AU - Leurs, R.

PY - 2013

Y1 - 2013

N2 - The basic methylpiperazine moiety is considered a necessary substructure for high histamine H

AB - The basic methylpiperazine moiety is considered a necessary substructure for high histamine H

U2 - 10.1021/jm301886t

DO - 10.1021/jm301886t

M3 - Article

VL - 2013

SP - 4264

EP - 4276

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 56

ER -

Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

Abstract

Access to Document

Fingerprint

Cite this