Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

H. Engelhardt, S. Schultes, C. de Graaf, S. Nijmeijer, H.F. Vischer, O.B. Zuiderveld, J. Dobler, K. Stachurski, M. Mayer, H. Arnhof, D. Scharn, E.J.J. Haaksma, I.J.P. de Esch, R. Leurs

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The basic methylpiperazine moiety is considered a necessary substructure for high histamine H
Original languageEnglish
Pages (from-to)4264-4276
JournalJournal of Medicinal Chemistry
Volume2013
Issue number56
DOIs
Publication statusPublished - 2013

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Histamine Receptors
Structure-Activity Relationship
Histamine
Ligands

Cite this

Engelhardt, H. ; Schultes, S. ; de Graaf, C. ; Nijmeijer, S. ; Vischer, H.F. ; Zuiderveld, O.B. ; Dobler, J. ; Stachurski, K. ; Mayer, M. ; Arnhof, H. ; Scharn, D. ; Haaksma, E.J.J. ; de Esch, I.J.P. ; Leurs, R. / Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode. In: Journal of Medicinal Chemistry. 2013 ; Vol. 2013, No. 56. pp. 4264-4276.
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title = "Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode",
abstract = "The basic methylpiperazine moiety is considered a necessary substructure for high histamine H",
author = "H. Engelhardt and S. Schultes and {de Graaf}, C. and S. Nijmeijer and H.F. Vischer and O.B. Zuiderveld and J. Dobler and K. Stachurski and M. Mayer and H. Arnhof and D. Scharn and E.J.J. Haaksma and {de Esch}, I.J.P. and R. Leurs",
year = "2013",
doi = "10.1021/jm301886t",
language = "English",
volume = "2013",
pages = "4264--4276",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
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Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode. / Engelhardt, H.; Schultes, S.; de Graaf, C.; Nijmeijer, S.; Vischer, H.F.; Zuiderveld, O.B.; Dobler, J.; Stachurski, K.; Mayer, M.; Arnhof, H.; Scharn, D.; Haaksma, E.J.J.; de Esch, I.J.P.; Leurs, R.

In: Journal of Medicinal Chemistry, Vol. 2013, No. 56, 2013, p. 4264-4276.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Bispyrimidines as potent histamine H4 receptor ligands: delineation of structure activity relationships and detailed H4 receptor binding mode

AU - Engelhardt, H.

AU - Schultes, S.

AU - de Graaf, C.

AU - Nijmeijer, S.

AU - Vischer, H.F.

AU - Zuiderveld, O.B.

AU - Dobler, J.

AU - Stachurski, K.

AU - Mayer, M.

AU - Arnhof, H.

AU - Scharn, D.

AU - Haaksma, E.J.J.

AU - de Esch, I.J.P.

AU - Leurs, R.

PY - 2013

Y1 - 2013

N2 - The basic methylpiperazine moiety is considered a necessary substructure for high histamine H

AB - The basic methylpiperazine moiety is considered a necessary substructure for high histamine H

U2 - 10.1021/jm301886t

DO - 10.1021/jm301886t

M3 - Article

VL - 2013

SP - 4264

EP - 4276

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 56

ER -