Abstract
Background: Periodontitis is a chronic inflammatory gum disease associated with systemic diseases such as cardiovascular diseases. Aim: To investigate the association of systemic blood biomarkers, C-reactive protein (CRP), levels of lipopolysaccharide (LPS), and IgG levels against periodontal pathogens Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) with the stability, based on the aortic diameter, the growth rate and the eligibility for surgical intervention, of patients with abdominal aortic aneurysm (AAA). Methods: Patients with stable AAA (n = 30) and unstable AAA (n = 31) were recruited. The anti-A. actinomycetemcomitans and anti-P. gingivalis IgG levels were analyzed by ELISA, the LPS analysis was performed by using the limulus amebocyte lysate (LAL) test, and plasma levels of CRP were determined using an immune turbidimetric method. The association between these blood systemic biomarkers, AAA features, periodontal clinical parameters and oral microbial profiles were explored. Regression models were used to test the relationship between variables. Results: The presence of antibodies against Pg and Aa, LPS and high CRP concentrations were found in all AAA patients. The IgG levels were similar in patients with stable and unstable AAA (both for Aa and Pg). Among investigated blood biomarkers, only CRP was associated with AAA stability. The amount of LPS in saliva, supra, and subgingival plaque were significantly associated with the systemic LPS (p <0.05). Conclusions: This post-hoc study emphasizes the presence of antibodies against Pg and Aa, LPS and high CRP concentrations in all AAA patients. The presence of Pg in saliva and subgingival plaque was significantly associated with the blood LPS levels. For further studies investigating periodontitis and systemic diseases, specific predictive blood biomarkers should be considered instead of the use of antibodies alone.
| Original language | English |
|---|---|
| Article number | 766462 |
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Frontiers in Cellular and Infection Microbiology |
| Volume | 11 |
| Issue number | January |
| Early online date | 14 Jan 2022 |
| DOIs | |
| Publication status | Published - Jan 2022 |
Bibliographical note
Funding Information:The authors are thankful to Mrs. L. Seidel (Department of Biostatistics and Medico-economic Information, University Hospital, CHU of Li?ge, Belgium), to Pr. A. Albert (Department of Public Health Sciences, University of Li?ge, Belgium), to Dr. A. Gau-Okroglic (Department of medical Imaging, University of Li?ge, Belgium), and to Dr. D. Deng (Department of Preventive Dentistry, ACTA, the Netherlands) for their collaboration.
Publisher Copyright:
Copyright © 2022 Salhi, Rijkschroeff, Van Hede, Laine, Teughels, Sakalihasan and Lambert.
Funding
The authors are thankful to Mrs. L. Seidel (Department of Biostatistics and Medico-economic Information, University Hospital, CHU of Li?ge, Belgium), to Pr. A. Albert (Department of Public Health Sciences, University of Li?ge, Belgium), to Dr. A. Gau-Okroglic (Department of medical Imaging, University of Li?ge, Belgium), and to Dr. D. Deng (Department of Preventive Dentistry, ACTA, the Netherlands) for their collaboration.
| Funders | Funder number |
|---|---|
| Department of Preventive Dentistry | |
| Department of Public Health Sciences | |
| Department of medical Imaging, University of Liège | |
| University Hospitals | |
| Alliance for California Traditional Arts | |
| Chung Hua University | |
| Université de Liège |
Keywords
- abdominal aortic aneurysm (AAA)
- inflammation and innate immunity
- microbiome
- periodontitis
- periodontitis systemic interaction
