Blood group chimerism in human multiple birth is not rare

B.A. van Dijk, D.I. Boomsma, A.J.M. de Man

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Abstract

Twin blood group chimerism seems to be very rare in humans. The 30–40 previously reported cases usually were found by mere coincidence during routine blood grouping in hospitals or blood banks. Usually in these cases frank blood group mixtures of, for example, 50/50%, 25/75%, or 5/95% at most were seen. Smaller percentages are very difficult to notice during routine work‐up. Using a sensitive fluorescence technique (sensitivity >0.01%) we detected blood group chimerism in 32/415 (8%) twin pairs and 12/57 (21%) triplet pairs, respectively, which is a higher incidence than reported previously.
Original languageEnglish
Pages (from-to)264-268
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume61
Issue number3
DOIs
Publication statusPublished - 22 Jan 1996

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