Body mass index is related to microvascular vasomotion, this is partly explained by adiponectin.

M.P. de Boer, N.J. Wijnstok, E.H. Serne, E.C. Eringa, C.D.A. Stehouwer, A. Flyvbjerg, T. Hoekstra, M.W. Heijmans, R.I. Meijer, J. Twisk, Y. Smulders

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective: obesity-related microvascular dysfunction, including alterations in rhythmic changes in vascular diameter, so-called 'vasomotion', may be important in the clustering of obesity with other cardiovascular risk factors. Adipokines have been suggested to play a role in obesity-related vascular dysfunction. Alterations in vasomotion have been found using extreme body mass index (BMI) phenotypes. Whether these alterations can be translated to the general population is unknown. The aim was to retrospectively investigate relationships between BMI, vasomotion and adipokines in a population-based cohort. Methods: Adiposity, vasomotion, adiponectin and leptin were determined in 94 apparently healthy participants (age 42 years, 46 men, mean BMI 25·5 ± 3·8 kg/m
Original languageEnglish
Pages (from-to)660-7
JournalEuropean Journal of Clinical Investigation
Volume44
Issue number7
DOIs
Publication statusPublished - 2014

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