Bone morphogenetic protein-2 incorporated calcium phosphate graft promotes peri-implant bone defect healing in dogs: A pilot study

Henri J.J. Uijlenbroek, Xingnan Lin, Tie Liu, Yuanna Zheng, Daniel Wismeijer, Yuelian Liu*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objectives: The evaluation of three different drug delivery modes of bone morphogenetic protein-2 (BMP-2) in healing peri-implant bone defects in beagle dogs. BMP-2 was incorporated in or onto calcium phosphate (CaP) granules in various ways: (i) directly on the outer layer of granules CaP: as an adsorbed depot; (ii) during the entire precipitation process of CaP: an internally incorporated depot; or (iii) during the biomimetic coating precipitation of BMP-2 on the surface of CaP granules: as a coating incorporated depot. Material and Methods: After extraction of the lower molars and wound healing in 6 male beagle dogs, 36 implants were placed (n = 6 animal per group). Peri-implant bone defects were induced. The following treatment groups were evaluated: no treatment; air abrasive surface cleaning (SC) using hydroxyapatite; SC and the subsequent filling of the defect with CaP without BMP-2; SC plus the subsequent filling of the defect with CaP adsorbed BMP-2; SC plus the subsequent filling of the defect with CaP internally incorporated BMP-2; SC plus the subsequent filling of the defect with CaP coating incorporated BMP-2. Histological and histomorphometric analyses were carried out to quantify and compare the changes in bone tissue surrounding the treated implants. Results: In Group 1 with no treatment, four implants were lost. Group 5 with the SC and the subsequent filling of the defect with internally incorporated BMP-2 biomimetically prepared CaP (BioCaP), whereby the BMP-2 is incorporated in the entire volume of all BioCaP particles, showed overall the best results to regenerate bone around the implants. Conclusion: This study concluded that the group treated with SC plus the subsequent filling of the defect with CaP BMP-2 internally incorporated BMP-2, whereby BMP-2 has been incorporated in the entire volume of all CaP particles, showed overall the best results when aiming to regenerate bone around the implants.

Original languageEnglish
Pages (from-to)1092-1102
Number of pages11
JournalClinical and Experimental Dental Research
Volume8
Issue number5
Early online date7 Jul 2022
DOIs
Publication statusPublished - Oct 2022

Bibliographical note

Funding Information:
The authors would like to thank Dr. Su Naichuan for his assistance with the statistical analysis. This study was partly supported by the Straumann company, which provided the dental implants. This study was supported by ITI Research Grant 889_2012.

Publisher Copyright:
© 2022 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.

Funding

The authors would like to thank Dr. Su Naichuan for his assistance with the statistical analysis. This study was partly supported by the Straumann company, which provided the dental implants. This study was supported by ITI Research Grant 889_2012.

Keywords

  • biomimetics
  • BMP-2
  • bone morphogenetic proteins
  • calcium phosphate
  • dogs
  • peri-implantitis

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