Bone muscle interactions and vitamin D

J.E. Gunton, C.M. Girgis, P.A. Baldock, P. Lips

    Research output: Contribution to JournalArticleAcademicpeer-review


    Beyond the established roles of vitamin D in bone and mineral homeostasis, we are becoming increasingly aware of its diverse effects in skeletal muscle. Subjects with severe vitamin D deficiency or mutations of the vitamin D receptor develop generalized atrophy of muscle and bone, suggesting coordinated effects of vitamin D in musculoskeletal physiology. At a mechanistic level, vitamin D exerts wide-ranging effects in muscle and bone calcium handling, differentiation and development. Vitamin D also modulates muscle and bone-derived hormones, facilitating cross-talk between these tissues. In this review, we discuss emerging evidence that vitamin D regulates bone and muscle in a direct, integrated fashion, positioning the vitamin D pathway as a potential therapeutic target for musculoskeletal diseases.This article is part of a Special Issue entitled "Muscle Bone Interactions".
    Original languageEnglish
    Pages (from-to)89-94
    Publication statusPublished - 2015


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