Breakpoint identification and smoothing of array comparative genomic hybridization data

C. Jong; E. Marchiori; G.J. Meijer; A.W. van der Vaart; B. Ylstra

doi:10.1093/bioinformatics/bth355

Breakpoint identification and smoothing of array comparative genomic hybridization data

C. Jong, E. Marchiori, G.J. Meijer, A.W. van der Vaart, B. Ylstra

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Abstract

Summary: We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data. © Oxford University Press 2004; all rights reserved.

Original language	English
Pages (from-to)	3636-3637
Journal	Bioinformatics
Volume	20
Issue number	18
DOIs	https://doi.org/10.1093/bioinformatics/bth355
Publication status	Published - 2004

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title = "Breakpoint identification and smoothing of array comparative genomic hybridization data",

abstract = "Summary: We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data. {\textcopyright} Oxford University Press 2004; all rights reserved.",

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AU - Jong, C.

AU - Marchiori, E.

AU - Meijer, G.J.

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AU - Ylstra, B.

PY - 2004

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N2 - Summary: We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data. © Oxford University Press 2004; all rights reserved.

AB - Summary: We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data. © Oxford University Press 2004; all rights reserved.

U2 - 10.1093/bioinformatics/bth355

DO - 10.1093/bioinformatics/bth355

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VL - 20

SP - 3636

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JO - Bioinformatics

JF - Bioinformatics

IS - 18

ER -

Breakpoint identification and smoothing of array comparative genomic hybridization data

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