Bridging cytoarchitectonics and connectomics in human cerebral cortex

Martijn P. van den Heuvel*, Lianne H. Scholtens, Lisa Feldman Barrett, Claus C. Hilgetag, Marcel A. de Reus

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


The rich variation in cytoarchitectonics of the human cortex is well known to play an important role in the differentiation of cortical information processing, with functional multimodal areas noted to display more branched, more spinous, and an overall more complex cytoarchitecture. In parallel, connectome studies have suggested that also the macroscale wiring profile of brain areas may have an important contribution in shaping neural processes; for example, multimodal areas have been noted to display an elaborate macroscale connectivity profile. However, how these two scales of brain connectivity are related—and perhaps interact—remains poorly understood. In this communication, we combined data from the detailed mappings of early twentieth century cytoarchitectonic pioneers Von Economo and Koskinas (1925) on the microscale cellular structure of the human cortex with data on macroscale connectome wiring as derived from high-resolution diffusion imaging data from the Human Connectome Project. In a cross-scale examination, we show evidence of a significant association between cytoarchitectonic features of human cortical organization—in particular the size of layer 3 neurons—and whole-brain corticocortical connectivity. Our findings suggest that aspects of microscale cytoarchitectonics and macroscale connectomics are related.

Original languageEnglish
Pages (from-to)13943-13948
Number of pages6
JournalThe Journal of Neuroscience
Issue number41
Publication statusPublished - 14 Oct 2015
Externally publishedYes


  • Connectivity
  • Connectomics
  • Cytoarchitectonics
  • Diffusion MRI
  • MRI
  • Pyramidal neuron


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