@inproceedings{cbdf3ae6745c4339a888f381a0c57881,
title = "Bringing third and second harmonic generation microscopy into the clinic for the assessment of fresh lung tissue",
abstract = "Third and second harmonic generation (THG/SHG) microscopy is a novel imaging technique that has been suggested as a promising clinical tool, mainly for cancer diagnosis. Here, we test for the first time a compact, transportable ex-vivo THG/SHG microscope (Tritos Diagnostics B.V.) for clinical use. In lung surgery, immediate feedback on the nature of the excised tissue is important. We will present the first results of an ongoing study in which we image both lung tumor tissue immediately after excision and frozen section biopsies, and compare the images to the golden standard histology. Prior to this study, we performed a set of experiments collecting 3D images of mouse lung tissue to show that the combination of THG and SHG microscopy reveals key lung morphology components.",
keywords = "Clinic, Lung tissue, Second harmonic generation microscopy, Third harmonic generation microscopy, Validation",
author = "{Van Huizen}, {Laura M.G.} and Dani{\"e}lle Seinstra and Chris Dickhoff and Teodora Radonic and Idris Bahce and {Van Mourik}, Frank and Annema, {Jouke T.} and Daniels, {Johannes M.A.} and {Van Boven}, {Wim Jan P.} and Groot, {Marie Louise}",
year = "2019",
month = jul,
day = "22",
doi = "10.1117/12.2527899",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Lilge, {Lothar D.} and Philipp, {Carsten M.}",
booktitle = "Medical Laser Applications and Laser-Tissue Interactions IX",
address = "United States",
note = "Medical Laser Applications and Laser-Tissue Interactions IX 2019 ; Conference date: 23-06-2019 Through 24-06-2019",
}
