TY - GEN
T1 - Building a Library of Eligibility Criteria to support design of clinical trials
AU - Milian, K.
AU - Bucur, A.
AU - van Harmelen, F.
PY - 2012
Y1 - 2012
N2 - The completion of clinical trial depends on sufficient participant enrollment, which is often problematic due to the restrictiveness of eligibility criteria, and effort required to verify patient eligibility. The objective of this research is to support the design of eligibility criteria, enable the reuse of structured criteria and to provide meaningful suggestions of relaxing them based on previous trials. The paper presents the first steps, a method for automatic comparison of criteria content and the library of structured and ordered eligibility criteria that can be browsed with the fine-grained queries. The structured representation consists of the automatically identified contextual patterns and semantic entities. The comparison of criteria is based on predefined relations between the patterns, concept equivalences defined in medical ontologies, and finally on threshold values. The results are discussed from the perspective of the scope of the eligibility criteria covered by our library.
AB - The completion of clinical trial depends on sufficient participant enrollment, which is often problematic due to the restrictiveness of eligibility criteria, and effort required to verify patient eligibility. The objective of this research is to support the design of eligibility criteria, enable the reuse of structured criteria and to provide meaningful suggestions of relaxing them based on previous trials. The paper presents the first steps, a method for automatic comparison of criteria content and the library of structured and ordered eligibility criteria that can be browsed with the fine-grained queries. The structured representation consists of the automatically identified contextual patterns and semantic entities. The comparison of criteria is based on predefined relations between the patterns, concept equivalences defined in medical ontologies, and finally on threshold values. The results are discussed from the perspective of the scope of the eligibility criteria covered by our library.
UR - https://www.scopus.com/pages/publications/84867679587
UR - https://www.scopus.com/inward/citedby.url?scp=84867679587&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-33876-2_29
DO - 10.1007/978-3-642-33876-2_29
M3 - Conference contribution
SN - 9783642338755
T3 - Lecture Notes in Computer Science (LNCS). Lecture Notes in Artificial Intelligence (LNAI)
SP - 327
EP - 336
BT - Knowledge Engineering and Knowledge Management
A2 - ten Teije, A
A2 - Völker, J
A2 - Handschuh, S
A2 - Stuckenschmidt, H
A2 - d’Acquin, M
A2 - Nikolov, A
A2 - Aussenac-Gilles, N
A2 - Hernandez, N
PB - Springer
CY - Berlin, Heidelberg
T2 - Knowledge Engineering and Knowledge Management
Y2 - 8 October 2012 through 12 October 2012
ER -