C-reactive protein and glucose regulation in familial longevity

Maarten P. Rozing, Simon P. Mooijaart, Marian Beekman, Carolien A. Wijsman, Andrea B. Maier, Andrzej Bartke, Rudi G J Westendorp, Eline P. Slagboom, Diana Van Heemst*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


Earlier, we showed that the offspring from exceptionally long-lived families have a more favorable glucose metabolism when compared with controls. As chronic low-grade inflammation has been regarded as a strong risk factor for insulin resistance, we evaluated if and to what extent the favorable glucose metabolism in offspring from long-lived families could be explained by differences in subclinical inflammation, as estimated from circulating levels of C-reactive protein. We found no difference between the two groups in C-reactive protein levels or in the distribution of C-reactive protein haplotypes. However, among controls higher levels of C-reactive protein were related to higher glucose levels, whereas among offspring levels of C-reactive protein were unrelated to glucose levels. It is a limitation of the current study that its cross-sectional nature does not allow for assessment of cause-effect relationships. One possible interpretation of these data is that the offspring from long-lived families might be able to regulate glucose levels more tightly under conditions of low-grade inflammation. To test this hypothesis, our future research will be focused on assessing the robustness of insulin sensitivity in response to various challenges in offspring from long-lived families and controls.

Original languageEnglish
Pages (from-to)623-630
Number of pages8
Issue number4
Publication statusPublished - Dec 2011


  • C-reactive protein
  • Humans
  • Insulin resistance
  • Longevity


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