Cadmium affects toxicokinetics of pyrene in the collembolan Folsomia candida.

M. Broerse, H. Oorsprong, C.A.M. van Gestel

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Since toxicity is time dependent, short-term toxicity tests may overlook mixture effects, because chemical accumulation within an organism takes time. We therefore studied the effects of cadmium on the toxicokinetics of pyrene and its metabolites in the soil-dwelling collembolan Folsomia candida exposed through Lufa 2.2 soil. Single pyrene was rapidly taken up and steady state was reached within the 337-h exposure period. Simultaneous exposure to cadmium significantly decreased the pyrene uptake and elimination rate, resulting in a prolonged half life. Kinetics of the first phase metabolite OHpyrene was also significantly influenced by cadmium. Cadmium increased the hydroxylation rate of pyrene but slowed down its further metabolization, again resulting in a prolonged half life. We showed that pyrene accumulation and metabolization are significantly influenced by the presence of cadmium. Our results suggest that mixture effects may be dependent on exposure time. © 2012 The Author(s).
Original languageEnglish
Pages (from-to)795-802
JournalEcotoxicology
Volume21
DOIs
Publication statusPublished - 2012

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Candida
Cadmium
pyrene
cadmium
Metabolites
half life
Half-Life
Toxicity
metabolite
Soil
Soils
Toxicity Tests
Hydroxylation
toxicity test
soil
Toxicokinetics
toxicity
kinetics
Kinetics
exposure

Cite this

@article{31f3dec60f40469c91d33c6d0750ebc3,
title = "Cadmium affects toxicokinetics of pyrene in the collembolan Folsomia candida.",
abstract = "Since toxicity is time dependent, short-term toxicity tests may overlook mixture effects, because chemical accumulation within an organism takes time. We therefore studied the effects of cadmium on the toxicokinetics of pyrene and its metabolites in the soil-dwelling collembolan Folsomia candida exposed through Lufa 2.2 soil. Single pyrene was rapidly taken up and steady state was reached within the 337-h exposure period. Simultaneous exposure to cadmium significantly decreased the pyrene uptake and elimination rate, resulting in a prolonged half life. Kinetics of the first phase metabolite OHpyrene was also significantly influenced by cadmium. Cadmium increased the hydroxylation rate of pyrene but slowed down its further metabolization, again resulting in a prolonged half life. We showed that pyrene accumulation and metabolization are significantly influenced by the presence of cadmium. Our results suggest that mixture effects may be dependent on exposure time. {\circledC} 2012 The Author(s).",
author = "M. Broerse and H. Oorsprong and {van Gestel}, C.A.M.",
year = "2012",
doi = "10.1007/s10646-011-0839-2",
language = "English",
volume = "21",
pages = "795--802",
journal = "Ecotoxicology",
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Cadmium affects toxicokinetics of pyrene in the collembolan Folsomia candida. / Broerse, M.; Oorsprong, H.; van Gestel, C.A.M.

In: Ecotoxicology, Vol. 21, 2012, p. 795-802.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Cadmium affects toxicokinetics of pyrene in the collembolan Folsomia candida.

AU - Broerse, M.

AU - Oorsprong, H.

AU - van Gestel, C.A.M.

PY - 2012

Y1 - 2012

N2 - Since toxicity is time dependent, short-term toxicity tests may overlook mixture effects, because chemical accumulation within an organism takes time. We therefore studied the effects of cadmium on the toxicokinetics of pyrene and its metabolites in the soil-dwelling collembolan Folsomia candida exposed through Lufa 2.2 soil. Single pyrene was rapidly taken up and steady state was reached within the 337-h exposure period. Simultaneous exposure to cadmium significantly decreased the pyrene uptake and elimination rate, resulting in a prolonged half life. Kinetics of the first phase metabolite OHpyrene was also significantly influenced by cadmium. Cadmium increased the hydroxylation rate of pyrene but slowed down its further metabolization, again resulting in a prolonged half life. We showed that pyrene accumulation and metabolization are significantly influenced by the presence of cadmium. Our results suggest that mixture effects may be dependent on exposure time. © 2012 The Author(s).

AB - Since toxicity is time dependent, short-term toxicity tests may overlook mixture effects, because chemical accumulation within an organism takes time. We therefore studied the effects of cadmium on the toxicokinetics of pyrene and its metabolites in the soil-dwelling collembolan Folsomia candida exposed through Lufa 2.2 soil. Single pyrene was rapidly taken up and steady state was reached within the 337-h exposure period. Simultaneous exposure to cadmium significantly decreased the pyrene uptake and elimination rate, resulting in a prolonged half life. Kinetics of the first phase metabolite OHpyrene was also significantly influenced by cadmium. Cadmium increased the hydroxylation rate of pyrene but slowed down its further metabolization, again resulting in a prolonged half life. We showed that pyrene accumulation and metabolization are significantly influenced by the presence of cadmium. Our results suggest that mixture effects may be dependent on exposure time. © 2012 The Author(s).

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DO - 10.1007/s10646-011-0839-2

M3 - Article

VL - 21

SP - 795

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JO - Ecotoxicology

JF - Ecotoxicology

SN - 0963-9292

ER -