Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 795-802 |
| Journal | Ecotoxicology |
| Volume | 21 |
| DOIs | |
| Publication status | Published - 2012 |
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Cadmium affects toxicokinetics of pyrene in the collembolan Folsomia candida. / Broerse, M.; Oorsprong, H.; van Gestel, C.A.M.
In: Ecotoxicology, Vol. 21, 2012, p. 795-802.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - Cadmium affects toxicokinetics of pyrene in the collembolan Folsomia candida.
AU - Broerse, M.
AU - Oorsprong, H.
AU - van Gestel, C.A.M.
PY - 2012
Y1 - 2012
N2 - Since toxicity is time dependent, short-term toxicity tests may overlook mixture effects, because chemical accumulation within an organism takes time. We therefore studied the effects of cadmium on the toxicokinetics of pyrene and its metabolites in the soil-dwelling collembolan Folsomia candida exposed through Lufa 2.2 soil. Single pyrene was rapidly taken up and steady state was reached within the 337-h exposure period. Simultaneous exposure to cadmium significantly decreased the pyrene uptake and elimination rate, resulting in a prolonged half life. Kinetics of the first phase metabolite OHpyrene was also significantly influenced by cadmium. Cadmium increased the hydroxylation rate of pyrene but slowed down its further metabolization, again resulting in a prolonged half life. We showed that pyrene accumulation and metabolization are significantly influenced by the presence of cadmium. Our results suggest that mixture effects may be dependent on exposure time. © 2012 The Author(s).
AB - Since toxicity is time dependent, short-term toxicity tests may overlook mixture effects, because chemical accumulation within an organism takes time. We therefore studied the effects of cadmium on the toxicokinetics of pyrene and its metabolites in the soil-dwelling collembolan Folsomia candida exposed through Lufa 2.2 soil. Single pyrene was rapidly taken up and steady state was reached within the 337-h exposure period. Simultaneous exposure to cadmium significantly decreased the pyrene uptake and elimination rate, resulting in a prolonged half life. Kinetics of the first phase metabolite OHpyrene was also significantly influenced by cadmium. Cadmium increased the hydroxylation rate of pyrene but slowed down its further metabolization, again resulting in a prolonged half life. We showed that pyrene accumulation and metabolization are significantly influenced by the presence of cadmium. Our results suggest that mixture effects may be dependent on exposure time. © 2012 The Author(s).
U2 - 10.1007/s10646-011-0839-2
DO - 10.1007/s10646-011-0839-2
M3 - Article
VL - 21
SP - 795
EP - 802
JO - Ecotoxicology
JF - Ecotoxicology
SN - 0963-9292
ER -