Calcium Phosphate and Silicate-Based Nanoparticles: History and Emerging Trends

Sabine Van Rijt, Klaas De Groot, Sander C.G. Leeuwenburgh*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Calcium phosphates (CaPs) and silicate-based bioglasses have been extensively studied since the early 1970s due to their unique capacity to bind to host bone, which led to their clinical translation and commercialization in the 1980s. Since the mid-1990s, researchers have synthesized nanoscale CaP and silicate-based particles of increased specific surface area, chemical reactivity, and solubility, which offer specific advantages compared to their bulk counterparts. This review provides a critical perspective on the history and emerging trends of these two classes of ceramic nanoparticles. Their synthesis and functional properties in terms of particle composition, size, shape, charge, dispersion, and toxicity are discussed as a function of relevant processing parameters. Specifically, emerging trends such as the influence of ion doping and mesoporosity on the biological and pharmaceutical performance of these nanoparticles are reviewed in more detail. Finally, a broad comparative overview is provided on the physicochemical properties and applicability of CaP and silicate-based nanoparticles within the fields of (i) local delivery of therapeutic agents, (ii) functionalization of biomaterial scaffolds or implant coatings, and (iii) bioimaging applications. This review provides a critical perspective on the history and emerging trends of the two main classes of bioceramic nanoparticles, that is, calcium phosphate (CaP) and silicate-based nanoparticles. While most reviews in literature focus on either CaP or silicate-based nanoparticles, our review evaluates both classes of bioceramic nanoparticles simultaneously. This combined review offers the opportunity to analyze differences and similarities with respect to the historic development and emerging trends within both fields of bioceramics research.

Original languageEnglish
Pages (from-to)461-477
Number of pages17
JournalTissue Engineering - Part A
Volume28
Issue number11-12
Early online date16 Jun 2022
DOIs
Publication statusPublished - Jun 2022

Bibliographical note

Publisher Copyright:
© Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.

Keywords

  • bioactive glass
  • bioceramics
  • bioglass
  • calcium phosphate
  • nanomedicine
  • nanoparticles

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