cAMP and excitability in neuroendocrine cells during reproductive senescence

C. Janse, M. van der Roest

    Research output: Contribution to JournalArticleAcademicpeer-review


    Excitability changes during reproductive senescence were investigated in the neurosecretory caudodorsal cells (CDCs) that control egg laying in the mollusc Lymnaea stagnalis. CDCs in the isolated central nervous system (CNS) were exposed to different discharge inducing treatments. Senescent CDCs (of animals 8 weeks after laying their last egg mass) and inhibited (I-) state CDCs (of egg-laying (EL) animals) were used. We showed that senescent and I-state CDCs closely resemble each other electrophysiologically. Electrical stimulation did not induce an afterdischarge in either type of CDC but exposure to release products of CDCs from EL animals or to saline with high potassium concentration did induce discharge activity. Also, 8-chlorophenylthio (8-CPT)-cAMP (10
    Original languageEnglish
    Pages (from-to)503-514
    Number of pages12
    JournalNeurobiology of Aging
    Publication statusPublished - 2001


    Dive into the research topics of 'cAMP and excitability in neuroendocrine cells during reproductive senescence'. Together they form a unique fingerprint.

    Cite this