Cancer Metabolism as a Therapeutic Target and Review of Interventions

Matthew T.J. Halma, Jack A. Tuszynski, Paul E. Marik*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention and better treatment outcomes. These interventions and their evidentiary basis are covered in the latter half of this review to guide future cancer treatment.

Original languageEnglish
Article number4245
Pages (from-to)1-42
Number of pages42
JournalNutrients
Volume15
Issue number19
Early online date1 Oct 2023
DOIs
Publication statusPublished - 1 Oct 2023

Bibliographical note

This article belongs to the Special Issue: Editorial Board Members’ Collection Series: Dietary Patterns and Cancer.

Funding Information:
M.T.J.H. is supported by the European Union H2020 Marie-Sklowdowska Curie International Training Network AntiHelix (Grant Agreement no. 859853).

Publisher Copyright:
© 2023 by the authors.

Funding

M.T.J.H. is supported by the European Union H2020 Marie-Sklowdowska Curie International Training Network AntiHelix (Grant Agreement no. 859853).

Keywords

  • cancer metabolism
  • glycolysis
  • ketogenic diet
  • lifestyle interventions
  • repurposed drugs
  • Warburg effect

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