TY - JOUR
T1 - Candidate gene studies and the quest for the entrepreneurial gene
AU - van der Loos, Matthijs J.H.M.
AU - Koellinger, Philipp D.
AU - Groenen, Patrick J.F.
AU - Rietveld, Cornelius A.
AU - Rivadeneira, Fernando
AU - van Rooij, Frank J.A.
AU - Uitterlinden, A. G.
AU - Hofman, Albert
AU - Thurik, A. Roy
PY - 2011/10/1
Y1 - 2011/10/1
N2 - Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of the results. As an example, Nicolaou et al. (Small Bus Econ 36:151-155, 2011) report a significant association between a common genetic variant in the DRD3 gene and the tendency to be an entrepreneur. We fail to replicate this finding using a much larger, independent dataset. In addition, we discuss the candidate gene approach and give suggestions to avoid the publication of false positives.
AB - Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of the results. As an example, Nicolaou et al. (Small Bus Econ 36:151-155, 2011) report a significant association between a common genetic variant in the DRD3 gene and the tendency to be an entrepreneur. We fail to replicate this finding using a much larger, independent dataset. In addition, we discuss the candidate gene approach and give suggestions to avoid the publication of false positives.
KW - Candidate gene study
KW - Entrepreneurship
KW - Genetics
KW - Genome-wide association study
UR - http://www.scopus.com/inward/record.url?scp=80052928845&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052928845&partnerID=8YFLogxK
U2 - 10.1007/s11187-011-9339-2
DO - 10.1007/s11187-011-9339-2
M3 - Article
AN - SCOPUS:80052928845
VL - 37
SP - 269
EP - 275
JO - Small Business Economics
JF - Small Business Economics
SN - 0921-898X
IS - 3
ER -
