Candidate gene studies and the quest for the entrepreneurial gene

Matthijs J.H.M. van der Loos; Philipp D. Koellinger; Patrick J.F. Groenen; Cornelius A. Rietveld; Fernando Rivadeneira; Frank J.A. van Rooij; A. G. Uitterlinden; Albert Hofman; A. Roy Thurik

doi:10.1007/s11187-011-9339-2

Candidate gene studies and the quest for the entrepreneurial gene

Matthijs J.H.M. van der Loos, Philipp D. Koellinger, Patrick J.F. Groenen, Cornelius A. Rietveld, Fernando Rivadeneira, Frank J.A. van Rooij, A. G. Uitterlinden, Albert Hofman, A. Roy Thurik

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of the results. As an example, Nicolaou et al. (Small Bus Econ 36:151-155, 2011) report a significant association between a common genetic variant in the DRD3 gene and the tendency to be an entrepreneur. We fail to replicate this finding using a much larger, independent dataset. In addition, we discuss the candidate gene approach and give suggestions to avoid the publication of false positives.

Original language	English
Pages (from-to)	269-275
Number of pages	7
Journal	Small Business Economics
Volume	37
Issue number	3
DOIs	https://doi.org/10.1007/s11187-011-9339-2
Publication status	Published - 1 Oct 2011

Funding

Acknowledgments We would like to thank Dr. Tobias A. Knoch, Anis Abuseiris, Karol Estrada, Luc V. de Zeeuw, and Rob de Graaf, as well as their institutions, the Erasmus Grid Office, Erasmus MC Rotterdam, The Netherlands, and especially the national German MediGRID and Services@MediGRID part of the German D-Grid, both funded by the German Bundesministerium fuer Forschung und Technology under grants # 01 AK 803 A-H and # 01 IG 07015 G for access to their grid resources.

Keywords

Candidate gene study
Entrepreneurship
Genetics
Genome-wide association study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11187-011-9339-2

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Cite this

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AU - Rivadeneira, Fernando

AU - van Rooij, Frank J.A.

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AU - Thurik, A. Roy

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Candidate gene studies and the quest for the entrepreneurial gene

Abstract

Funding

Keywords

UN SDGs

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