Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD

J. Bralten; B. Franke; I.D. Waldman; N.N.J. Rommelse; C. Hartman; P. Asherson; T. Banaschewski; R.P. Ebstein; M. Gill; A. Miranda; R.D. Oades; H. Roeyers; A. Rothenberger; J.A. Sergeant; J. Oosterlaan; E. Sonuga-Barke; H.C. Steinhausen; S. Faraone; J.K. Buitelaar; A. Arias-Vasquez

doi:10.1016/j.jaac.2013.08.020

Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD

J. Bralten, B. Franke, I.D. Waldman, N.N.J. Rommelse, C. Hartman, P. Asherson, T. Banaschewski, R.P. Ebstein, M. Gill, A. Miranda, R.D. Oades, H. Roeyers, A. Rothenberger, J.A. Sergeant, J. Oosterlaan, E. Sonuga-Barke, H.C. Steinhausen, S. Faraone, J.K. Buitelaar, A. Arias-Vasquez

Clinical Neuropsychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD. Method The pathway was described as a predefined gene selection based on a well-established database or literature data. Common genetic variants in pathways involved in dopamine/norepinephrine and serotonin neurotransmission and genes involved in neuritic outgrowth were investigated in cases from the International Multicentre ADHD Genetics (IMAGE) study. Multivariable analysis was performed to combine the effects of single genetic variants within the pathway genes. Phenotypes were DSM-IV symptom counts for inattention and hyperactivity/impulsivity (n = 871) and symptom severity measured with the Conners Parent (n = 930) and Teacher (n = 916) Rating Scales. Results Summing genetic effects of common genetic variants within the pathways showed a significant association with hyperactive/impulsive symptoms (p

Original language	English
Pages (from-to)	1204-1212
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	11
DOIs	https://doi.org/10.1016/j.jaac.2013.08.020
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jaac.2013.08.020

http://www.ncbi.nlm.nih.gov/pubmed/24157394

Persistent URL (handle)

Persistent link

Cite this

Bralten, J., Franke, B., Waldman, I. D., Rommelse, N. N. J., Hartman, C., Asherson, P., Banaschewski, T., Ebstein, R. P., Gill, M., Miranda, A., Oades, R. D., Roeyers, H., Rothenberger, A., Sergeant, J. A., Oosterlaan, J., Sonuga-Barke, E., Steinhausen, H. C., Faraone, S., Buitelaar, J. K., & Arias-Vasquez, A. (2013). Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 11, 1204-1212. https://doi.org/10.1016/j.jaac.2013.08.020

@article{6d10fa144bd4447789e7274642ceb499,

title = "Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD",

abstract = "Objective Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD. Method The pathway was described as a predefined gene selection based on a well-established database or literature data. Common genetic variants in pathways involved in dopamine/norepinephrine and serotonin neurotransmission and genes involved in neuritic outgrowth were investigated in cases from the International Multicentre ADHD Genetics (IMAGE) study. Multivariable analysis was performed to combine the effects of single genetic variants within the pathway genes. Phenotypes were DSM-IV symptom counts for inattention and hyperactivity/impulsivity (n = 871) and symptom severity measured with the Conners Parent (n = 930) and Teacher (n = 916) Rating Scales. Results Summing genetic effects of common genetic variants within the pathways showed a significant association with hyperactive/impulsive symptoms (p",

author = "J. Bralten and B. Franke and I.D. Waldman and N.N.J. Rommelse and C. Hartman and P. Asherson and T. Banaschewski and R.P. Ebstein and M. Gill and A. Miranda and R.D. Oades and H. Roeyers and A. Rothenberger and J.A. Sergeant and J. Oosterlaan and E. Sonuga-Barke and H.C. Steinhausen and S. Faraone and J.K. Buitelaar and A. Arias-Vasquez",

year = "2013",

doi = "10.1016/j.jaac.2013.08.020",

language = "English",

volume = "11",

pages = "1204--1212",

journal = "Journal of the American Academy of Child and Adolescent Psychiatry",

issn = "0890-8567",

publisher = "Elsevier Inc.",

}

Bralten, J, Franke, B, Waldman, ID, Rommelse, NNJ, Hartman, C, Asherson, P, Banaschewski, T, Ebstein, RP, Gill, M, Miranda, A, Oades, RD, Roeyers, H, Rothenberger, A, Sergeant, JA, Oosterlaan, J, Sonuga-Barke, E, Steinhausen, HC, Faraone, S, Buitelaar, JK & Arias-Vasquez, A 2013, 'Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 11, pp. 1204-1212. https://doi.org/10.1016/j.jaac.2013.08.020

Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD. / Bralten, J.; Franke, B.; Waldman, I.D. et al.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 11, 2013, p. 1204-1212.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD

AU - Bralten, J.

AU - Franke, B.

AU - Waldman, I.D.

AU - Rommelse, N.N.J.

AU - Hartman, C.

AU - Asherson, P.

AU - Banaschewski, T.

AU - Ebstein, R.P.

AU - Gill, M.

AU - Miranda, A.

AU - Oades, R.D.

AU - Roeyers, H.

AU - Rothenberger, A.

AU - Sergeant, J.A.

AU - Oosterlaan, J.

AU - Sonuga-Barke, E.

AU - Steinhausen, H.C.

AU - Faraone, S.

AU - Buitelaar, J.K.

AU - Arias-Vasquez, A.

PY - 2013

Y1 - 2013

N2 - Objective Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD. Method The pathway was described as a predefined gene selection based on a well-established database or literature data. Common genetic variants in pathways involved in dopamine/norepinephrine and serotonin neurotransmission and genes involved in neuritic outgrowth were investigated in cases from the International Multicentre ADHD Genetics (IMAGE) study. Multivariable analysis was performed to combine the effects of single genetic variants within the pathway genes. Phenotypes were DSM-IV symptom counts for inattention and hyperactivity/impulsivity (n = 871) and symptom severity measured with the Conners Parent (n = 930) and Teacher (n = 916) Rating Scales. Results Summing genetic effects of common genetic variants within the pathways showed a significant association with hyperactive/impulsive symptoms (p

AB - Objective Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD. Method The pathway was described as a predefined gene selection based on a well-established database or literature data. Common genetic variants in pathways involved in dopamine/norepinephrine and serotonin neurotransmission and genes involved in neuritic outgrowth were investigated in cases from the International Multicentre ADHD Genetics (IMAGE) study. Multivariable analysis was performed to combine the effects of single genetic variants within the pathway genes. Phenotypes were DSM-IV symptom counts for inattention and hyperactivity/impulsivity (n = 871) and symptom severity measured with the Conners Parent (n = 930) and Teacher (n = 916) Rating Scales. Results Summing genetic effects of common genetic variants within the pathways showed a significant association with hyperactive/impulsive symptoms (p

U2 - 10.1016/j.jaac.2013.08.020

DO - 10.1016/j.jaac.2013.08.020

M3 - Article

SN - 0890-8567

VL - 11

SP - 1204

EP - 1212

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

ER -

Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD

Abstract

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

Cite this