TY - JOUR
T1 - Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD
AU - Bralten, J.
AU - Franke, B.
AU - Waldman, I.D.
AU - Rommelse, N.N.J.
AU - Hartman, C.
AU - Asherson, P.
AU - Banaschewski, T.
AU - Ebstein, R.P.
AU - Gill, M.
AU - Miranda, A.
AU - Oades, R.D.
AU - Roeyers, H.
AU - Rothenberger, A.
AU - Sergeant, J.A.
AU - Oosterlaan, J.
AU - Sonuga-Barke, E.
AU - Steinhausen, H.C.
AU - Faraone, S.
AU - Buitelaar, J.K.
AU - Arias-Vasquez, A.
PY - 2013
Y1 - 2013
N2 - Objective Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD. Method The pathway was described as a predefined gene selection based on a well-established database or literature data. Common genetic variants in pathways involved in dopamine/norepinephrine and serotonin neurotransmission and genes involved in neuritic outgrowth were investigated in cases from the International Multicentre ADHD Genetics (IMAGE) study. Multivariable analysis was performed to combine the effects of single genetic variants within the pathway genes. Phenotypes were DSM-IV symptom counts for inattention and hyperactivity/impulsivity (n = 871) and symptom severity measured with the Conners Parent (n = 930) and Teacher (n = 916) Rating Scales. Results Summing genetic effects of common genetic variants within the pathways showed a significant association with hyperactive/impulsive symptoms (p
AB - Objective Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology of ADHD. Method The pathway was described as a predefined gene selection based on a well-established database or literature data. Common genetic variants in pathways involved in dopamine/norepinephrine and serotonin neurotransmission and genes involved in neuritic outgrowth were investigated in cases from the International Multicentre ADHD Genetics (IMAGE) study. Multivariable analysis was performed to combine the effects of single genetic variants within the pathway genes. Phenotypes were DSM-IV symptom counts for inattention and hyperactivity/impulsivity (n = 871) and symptom severity measured with the Conners Parent (n = 930) and Teacher (n = 916) Rating Scales. Results Summing genetic effects of common genetic variants within the pathways showed a significant association with hyperactive/impulsive symptoms (p
UR - https://www.scopus.com/pages/publications/84886400418
UR - https://www.scopus.com/inward/citedby.url?scp=84886400418&partnerID=8YFLogxK
U2 - 10.1016/j.jaac.2013.08.020
DO - 10.1016/j.jaac.2013.08.020
M3 - Article
SN - 0890-8567
VL - 11
SP - 1204
EP - 1212
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
ER -
